1
formal
: of or relating to an entire system
The company made some systemic changes to the way it operated.
The problem seems to be systemic.
2
medical
: of, relating to, or affecting the entire body
a systemic disease
Cite this Entry
“Systemic.” Merriam-Webster.com Simple Definition, Merriam-Webster, https://www.merriam-webster.com/simple/systemic. Accessed 22 Jun. 2026.
Copy Citation
