1
: large enough to be noticed or have an effect
A significant number of customers complained about the service.
He won a significant amount of money.
There is a significant difference in prices between the two stores.
The study found a statistically significant decrease in symptoms in patients who had taken the drug.
His influence on me was significant. = He had a significant influence on me.
2
: very important
a significant event in the history of our nation
Fish is a significant part of their diet.
It is significant that she never mentioned him.
3
: having a special or hidden meaning
He gave us a significant wink/look.
a significant [=suggestive] glance
Cite this Entry
“Significant.” Merriam-Webster.com Simple Definition, Merriam-Webster, https://www.merriam-webster.com/simple/significant. Accessed 22 Jun. 2026.
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