How to Use diphenhydramine in a Sentence
diphenhydramine
noun-
Benadryl is the brand name of the active drug diphenhydramine.
—Alex Yampolsky, Verywell Health, 10 Sep. 2024
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Benadryl is the brand name of diphenhydramine, used to treat allergies.
—Teri Figueroa, sandiegouniontribune.com, 10 May 2018
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This group includes many over-the-counter sleep medicines, such as those containing diphenhydramine.
—Dr. Keith Roach, oregonlive, 29 Mar. 2021
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One small study even found that diphenhydramine impaired driving more than alcohol.
—Emily Kay Votruba, EverydayHealth.com, 13 Aug. 2025
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Jennifer was driving—and was legally drunk—but didn’t show signs of having taken diphenhydramine.
—Lauren Smiley, Glamour, 5 Apr. 2019
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And that’s why diphenhydramine can be helpful to relive such allergy symptoms.
—Bruce Y. Lee, Forbes, 17 Apr. 2023
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Doxylamine and diphenhydramine are antihistamines that can be used as sleeping aids.
—Bruce Vielmetti, Milwaukee Journal Sentinel, 26 Feb. 2020
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The diphenhydramine in Benadryl helps to reduce the body's histamine response and treat the symptoms.
—Sherri Gordon, Parents, 9 July 2024
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Ask your provider about taking an antihistamine, such as Benadryl (diphenhydramine), to help with swelling or itching.
—Carrie Madormo, Verywell Health, 5 June 2025
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According to Albert, many other sleep aids on the market contain diphenhydramine.
—Fran Kritz, Verywell Health, 8 Jan. 2024
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That challenge prompted a warning from the FDA about the danger of high doses of diphenhydramine.
—Leada Gore | [email protected], al, 20 Sep. 2022
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Your child’s allergist can tell you when to give diphenhydramine and when to give epinephrine, if these medications have been prescribed.
—Hillary Gordon, Md, Philly.com, 30 Apr. 2018
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The report says methamphetamine, amphetamine and diphenhydramine were present in Jennette's blood.
—CNN, 21 May 2021
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In fact, honey might relieve cough symptoms better than no treatment, diphenhydramine, and a placebo, a 2018 study found.
—Ashley Martens, Women's Health, 20 July 2023
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By contrast, drowsy formulas containing diphenhydramine don’t interact with caffeine in this way.
—Khloe Quill, FOXNews.com, 5 Oct. 2025
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While some incidents involving diphenhydramine may be related to the challenge, officials note that others may be an attempt at self-harm.
—Staff Report, Hartford Courant, 10 June 2026
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The father overdosed on heroine, while the mother used a combination of methadone, dextrorphan, diphenhydramine and doxylamine.
—Andrea Fowler, Redbook, 30 Jan. 2015
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The boy’s death was classified as homicide from diphenhydramine (di-fen-HI-druh-meen) intoxication.
—San Diego Union-Tribune, 23 Aug. 2019
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Carefully review and follow medication labels to avoid giving more than one product containing diphenhydramine at the same time.
—T'keyah Bazin, Verywell Health, 30 May 2025
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Taking diphenhydramine improperly or in large amounts can affect the brain and heart, and can lead to serious or life-threatening effects, the advisory warned.
—Angelica Stabile, FOXNews.com, 19 June 2026
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This is the active ingredient in Unisom, a common sleep aid for insomnia that works similarly to diphenhydramine.
—Patty Weasler, Verywell Health, 24 Nov. 2025
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However, diphenhydramine, like many medications, is not without its side effects and potential dangers.
—Bruce Y. Lee, Forbes, 17 Apr. 2023
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For example, the active ingredient in Benadryl, diphenhydramine, is banned in Zambia in over-the counter products.
—New York Times, 19 Jan. 2018
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The agency also said Sarah Hart and two of the children who died in the crash had diphenhydramine, an active ingredient in Benadryl, in their systems.
—The Oregonian/oregonlive, OregonLive.com, 13 Apr. 2018
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Treatment for dermatitis caused by sea lice can include an antihistamine, such diphenhydramine, an over-the-counter hydrocortisone cream, calamine lotion, or an oatmeal bath.
—Caitlin O'Kane, CBS News, 27 June 2018
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Older antihistamines, such as Benadryl (diphenhydramine), are known to cause significant side effects such as drowsiness.
—Daniel More, Verywell Health, 9 Mar. 2024
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The most common active ingredients mentioned were diphenhydramine and dextromethorphan.
—Philly.com, 29 Aug. 2017
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That said, people with chronic insomnia will often self-medicate with over-the-counter medications such as Benadryl (diphenhydramine) or melatonin.
—Sherri Gordon, Health, 6 Aug. 2024
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The cameras captured Kozlowski on video repeatedly pouring diphenhydramine into his wife’s coffee.
—Harriet Sokmensuer, PEOPLE.com, 2 Aug. 2019
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Federal health officials have long warned about the dangers of taking excessive amounts of diphenhydramine, the active ingredient in Benadryl.
—Jordan Greene, PEOPLE, 16 June 2026
Some of these examples are programmatically compiled from various online sources to illustrate current usage of the word 'diphenhydramine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.
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