di·​phen·​hy·​dra·​mine | \ ˌdī-ˌfen-ˈhī-drə-ˌmēn How to pronounce diphenhydramine (audio) \

Definition of diphenhydramine

: an antihistamine C17H21NO used especially in the form of its hydrochloride

Examples of diphenhydramine in a Sentence

Recent Examples on the Web

Toxicology tests detected a common antihistamine called diphenhydramine and THC, the active ingredient of marijuana, in his system. Fox News, "Oklahoma City police say shooting of naked and unarmed teen was justified," 9 Aug. 2019 The Office of the Chief Medical Examiner in Washington said Friday that her death was an accident and was caused by intoxication from diphenhydramine, ethanol, phentermine, temazepam and zolpidem. Tom Steele, Dallas News, "Missy Shorey, first woman elected to lead Dallas County GOP, died from accidental mix of alcohol, sleeping aids," 2 Aug. 2019 The cameras captured Kozlowski on video repeatedly pouring diphenhydramine into his wife’s coffee. Harriet Sokmensuer, PEOPLE.com, "Man Who Repeatedly Poisoned His Wife's Coffee Gets 60 Days: 'Slap in the Face to the Victim'," 2 Aug. 2019 Jennifer was driving—and was legally drunk—but didn’t show signs of having taken diphenhydramine. Lauren Smiley, Glamour, "Sarah Hart Was ‘Intoxicated’: Everything We’ve Learned So Far About the Hart Family From the Coroner’s Inquest," 5 Apr. 2019 Common over-the-counter sleeping medications have one of four ingredients: melatonin, diphenhydramine, doxylamine, or valerian. Yvette D'entremont, SELF, "I'm a Scientist With Insomnia So I Researched How to Actually Get Better Sleep," 28 Nov. 2018 The coroner found diphenhydramine, an ingredient commonly found in allergy medicines like Benadryl, in the bodies of Sarah and two of the kids; Jen's blood alcohol content was over the legal limit. Lauren Smiley, Glamour, "Two White Moms. Six Black Kids. One Unthinkable Tragedy. A Look Inside the ‘Perfect’ Hart Family," 6 Sep. 2018 Treatment for dermatitis caused by sea lice can include an antihistamine, such diphenhydramine, an over-the-counter hydrocortisone cream, calamine lotion, or an oatmeal bath. Caitlin O'kane, CBS News, "Sea lice reported on Florida beach," 27 June 2018 Benadryl is the brand name of diphenhydramine, used to treat allergies. Teri Figueroa, sandiegouniontribune.com, "Did son kill mom with hammer in 'fog of Benadryl' after at least 80 allergy pills?," 10 May 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'diphenhydramine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of diphenhydramine

1948, in the meaning defined above

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Last Updated

11 Aug 2019

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Time Traveler for diphenhydramine

The first known use of diphenhydramine was in 1948

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di·​phen·​hy·​dra·​mine | \ ˌdī-ˌfen-ˈhī-drə-ˌmēn How to pronounce diphenhydramine (audio) \

Medical Definition of diphenhydramine

: an antihistamine used especially in the form of its hydrochloride C17H21NO·HCl to treat allergy symptoms and motion sickness and to induce sleep — see benadryl

More from Merriam-Webster on diphenhydramine

Britannica.com: Encyclopedia article about diphenhydramine

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