di·​phen·​hy·​dra·​mine | \ ˌdī-ˌfen-ˈhī-drə-ˌmēn \

Definition of diphenhydramine

: an antihistamine C17H21NO used especially in the form of its hydrochloride

Examples of diphenhydramine in a Sentence

Recent Examples on the Web

Common over-the-counter sleeping medications have one of four ingredients: melatonin, diphenhydramine, doxylamine, or valerian. Yvette D'entremont, SELF, "I'm a Scientist With Insomnia So I Researched How to Actually Get Better Sleep," 28 Nov. 2018 The coroner found diphenhydramine, an ingredient commonly found in allergy medicines like Benadryl, in the bodies of Sarah and two of the kids; Jen's blood alcohol content was over the legal limit. Lauren Smiley, Glamour, "Two White Moms. Six Black Kids. One Unthinkable Tragedy. A Look Inside the ‘Perfect’ Hart Family," 6 Sep. 2018 Treatment for dermatitis caused by sea lice can include an antihistamine, such diphenhydramine, an over-the-counter hydrocortisone cream, calamine lotion, or an oatmeal bath. Caitlin O'kane, CBS News, "Sea lice reported on Florida beach," 27 June 2018 Benadryl is the brand name of diphenhydramine, used to treat allergies. Teri Figueroa, sandiegouniontribune.com, "Did son kill mom with hammer in 'fog of Benadryl' after at least 80 allergy pills?," 10 May 2018 Your child’s allergist can tell you when to give diphenhydramine and when to give epinephrine, if these medications have been prescribed. Hillary Gordon, Md, Philly.com, "ER visits rising for kids with allergies," 30 Apr. 2018 The agency also said Sarah Hart and two of the children who died in the crash had diphenhydramine, an active ingredient in Benadryl, in their systems. The Oregonian/oregonlive, OregonLive.com, "Devonte Hart's biological mom: They gave my kids 'to monsters'," 13 Apr. 2018 For example, the active ingredient in Benadryl, diphenhydramine, is banned in Zambia in over-the counter products. New York Times, "How to Make Sure You Travel with Medication Legally," 19 Jan. 2018 The father overdosed on heroine, while the mother used a combination of methadone, dextrorphan, diphenhydramine and doxylamine. Andrea Fowler, Redbook, "Parents of Four Orchestrate Family Suicide Because They Fear "Evils in the World"," 30 Jan. 2015

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'diphenhydramine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of diphenhydramine

1948, in the meaning defined above

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Last Updated

29 Dec 2018

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Time Traveler for diphenhydramine

The first known use of diphenhydramine was in 1948

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di·​phen·​hy·​dra·​mine | \ ˌdī-ˌfen-ˈhī-drə-ˌmēn \

Medical Definition of diphenhydramine

: an antihistamine used especially in the form of its hydrochloride C17H21NO·HCl to treat allergy symptoms and motion sickness and to induce sleep — see benadryl

More from Merriam-Webster on diphenhydramine

Britannica.com: Encyclopedia article about diphenhydramine

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