di·​phen·​hy·​dra·​mine | \ ˌdī-ˌfen-ˈhī-drə-ˌmēn How to pronounce diphenhydramine (audio) \

Definition of diphenhydramine

: an antihistamine C17H21NO used especially in the form of its hydrochloride

Examples of diphenhydramine in a Sentence

Recent Examples on the Web Doxylamine and diphenhydramine are antihistamines that can be used as sleeping aids. Bruce Vielmetti, Milwaukee Journal Sentinel, "Former Cedarburg restaurant operator guilty in drink spiking case," 26 Feb. 2020 The cameras captured video of Brian Kozlowski pouring diphenhydramine, an antihistamine mainly used to treat allergies or for insomnia, into her coffee on multiple occasions, according to authorities. Janelle Griffith, NBC News, "Michigan man sentenced to 60 weekend days in jail for poisoning wife's coffee," 2 Aug. 2019 Those include sedatives such as aplrazolam (sold as Xanax), clonazepam (sold as Klonopin) and diazepam (sold as Valium), as well as the antihistamine diphenhydramine (sold as Benadryl), and a number of other powerful narcotics and opioids. Erika Edwards, NBC News, "The drugs behind deadly overdoses vary across the United States.," 25 Oct. 2019 The boy’s death was classified as homicide from diphenhydramine (di-fen-HI-druh-meen) intoxication. San Diego Union-Tribune, "Judge rejects Delaware woman’s appeal in daycare death," 23 Aug. 2019 Toxicology tests detected a common antihistamine called diphenhydramine and THC, the active ingredient of marijuana, in his system. Fox News, "Oklahoma City police say shooting of naked and unarmed teen was justified," 9 Aug. 2019 The Office of the Chief Medical Examiner in Washington said Friday that her death was an accident and was caused by intoxication from diphenhydramine, ethanol, phentermine, temazepam and zolpidem. Tom Steele, Dallas News, "Missy Shorey, first woman elected to lead Dallas County GOP, died from accidental mix of alcohol, sleeping aids," 2 Aug. 2019 The cameras captured Kozlowski on video repeatedly pouring diphenhydramine into his wife’s coffee. Harriet Sokmensuer, PEOPLE.com, "Man Who Repeatedly Poisoned His Wife's Coffee Gets 60 Days: 'Slap in the Face to the Victim'," 2 Aug. 2019 Jennifer was driving—and was legally drunk—but didn’t show signs of having taken diphenhydramine. Lauren Smiley, Glamour, "Sarah Hart Was ‘Intoxicated’: Everything We’ve Learned So Far About the Hart Family From the Coroner’s Inquest," 5 Apr. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'diphenhydramine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of diphenhydramine

1948, in the meaning defined above

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The first known use of diphenhydramine was in 1948

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Last Updated

9 Mar 2020

Cite this Entry

“Diphenhydramine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/diphenhydramine. Accessed 29 Mar. 2020.

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di·​phen·​hy·​dra·​mine | \ ˌdī-ˌfen-ˈhī-drə-ˌmēn How to pronounce diphenhydramine (audio) \

Medical Definition of diphenhydramine

: an antihistamine used especially in the form of its hydrochloride C17H21NO·HCl to treat allergy symptoms and motion sickness and to induce sleep — see benadryl

More from Merriam-Webster on diphenhydramine

Britannica.com: Encyclopedia article about diphenhydramine

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