Medical Definition of unicentric
: having a single center of origin a unicentric tumor For example, a pathologic analysis of 130 mastectomy specimens with primary tumors 2 cm or smaller found that only 41% had pathologically confirmed unicentric disease. A total of 42% of patients had multifocal or multicentric disease …— Grace L. Smith et al., The Journal of the American Medical Association, 2 May 2012
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