trazodone

noun

traz·​o·​done ˈtra-zə-ˌdōn How to pronounce trazodone (audio)
: an antidepressant drug C19H22ClN5O administered in the form of its hydrochloride

Examples of trazodone in a Sentence

Recent Examples on the Web
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By the end of January 2023, Lindsay had been prescribed a series of drugs, including Zoloft, trazodone, Prozac, Ambien, Remeron, Klonopin, and Seroquel. Colleen Cronin, Boston Herald, 22 Jan. 2026 Sleep medications — such as the antidepressants doxepin or trazodone or certain nonbenzodiazepine hypnotics — can be helpful short-term, Kaylor said. Kristen Rogers, CNN Money, 20 Nov. 2025 Your physician may also be able to prescribe an alternative treatment such as clonidine or trazodone. C. Michael White, The Conversation, 7 Nov. 2025 Some medications may make trazodone less effective. Jessica Swirble, Verywell Health, 17 Sep. 2025 Berry additionally said Dale had less than a therapeutic dose of trazodone in his system, and that a combination of it and alcohol could suppress a person’s respiratory system. Teri Figueroa, Mercury News, 4 Sep. 2025 The Cleveland Clinic lists trazodone, amitriptyline, clomipramine doxepin, fluoxetine, sertraline, phenelzine and rasagiline as possible culprits. Bruce Y. Lee, Forbes.com, 15 May 2025 The medications were for a range of drugs, but there were several empty prescription bottles for trazodone found, according to the warrant. Nicole Lopez, Fort Worth Star-Telegram, 22 June 2024

Word History

Etymology

perhaps from International Scientific Vocabulary triazo azido + pyridine + -one

First Known Use

1971, in the meaning defined above

Time Traveler
The first known use of trazodone was in 1971

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Cite this Entry

“Trazodone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/trazodone. Accessed 2 Apr. 2026.

Medical Definition

trazodone

noun
traz·​o·​done ˈtraz-ə-ˌdōn How to pronounce trazodone (audio)
: an antidepressant drug that is administered in the form of its hydrochloride C19H22ClN5O·HCl and inhibits the uptake of serotonin by the brain

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