Medical Dictionary

sirolimus

noun si·ro·li·mus \ si-ˈrō-li-məs \

medical Definition of sirolimus

:an immunosuppressive drug C51H79NO13 that is a macrocyclic lactone obtained from a soil bacterium of the genus Streptomyces (S. hygroscopicus) and is taken orally especially to prevent rejection of transplanted organs
  • Sirolimus (also called rapamycin) is a macrolide antibiotic that blocks proliferative responses of lymphocytes to interleukin-2 by inhibiting interleukin-2-mediated signal-transduction events.
  • —Manuel Pascual et al.The New England Journal of Medicine21 Feb. 2002
called also rapamycin
Note: Sirolimus is often taken in combination with other immunosuppressive drugs (such as cyclosporine) and is marketed under the trademark Rapamune.

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