Medical Definition of sirolimus
: an immunosuppressive drug C51H79NO13 that is a macrocyclic lactone obtained from a soil bacterium of the genus Streptomyces (S. hygroscopicus) and is taken orally especially to prevent rejection of transplanted organs Sirolimus (also called rapamycin) is a macrolide antibiotic that blocks proliferative responses of lymphocytes to interleukin-2 by inhibiting interleukin-2-mediated signal-transduction events.—Manuel Pascual et al., The New England Journal of Medicine, 21 Feb. 2002—called also rapamycin ◆Sirolimus is often taken in combination with other immunosuppressive drugs (such as cyclosporine) and is marketed under the trademark Rapamune.
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