Medical Dictionary

sirolimus

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noun si·ro·li·mus \si-ˈrō-li-məs\

Medical Definition of sirolimus

  1. :  an immunosuppressive drug C51H79NO13 that is a macrocyclic lactone obtained from a soil bacterium of the genus Streptomyces (S. hygroscopicus) and is taken orally especially to prevent rejection of transplanted organs Sirolimus (also called rapamycin) is a macrolide antibiotic that blocks proliferative responses of lymphocytes to interleukin-2 by inhibiting interleukin-2-mediated signal-transduction events.—Manuel Pascual et al., The New England Journal of Medicine, 21 Feb. 2002—called also rapamycin Sirolimus is often taken in combination with other immunosuppressive drugs (such as cyclosporine) and is marketed under the trademark Rapamune.


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