si·​ro·​li·​mus si-ˈrō-li-məs How to pronounce sirolimus (audio)
: an immunosuppressive drug C51H79NO13 that is a macrocyclic lactone obtained from a soil bacterium of the genus Streptomyces (S. hygroscopicus) and is taken orally especially to prevent rejection of transplanted organs
Sirolimus (also called rapamycin) is a macrolide antibiotic that blocks proliferative responses of lymphocytes to interleukin-2 by inhibiting interleukin-2-mediated signal-transduction events.Manuel Pascual et al., The New England Journal of Medicine

called also rapamycin

Note: Sirolimus is often taken in combination with other immunosuppressive drugs (such as cyclosporine) and is marketed under the trademark Rapamune.

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Cite this Entry

“Sirolimus.” Medical Dictionary, Merriam-Webster, Accessed 28 Nov. 2023.

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