rheumatoid factor

noun

: an autoantibody of high molecular weight that reacts against IgG immunoglobulins and is often present in rheumatoid arthritis

Examples of rheumatoid factor in a Sentence

Recent Examples on the Web
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These can check for particular antibodies like Anti-SSA (Ro) and Anti-SSB (La) ones, as well as ANA and rheumatoid factor. Bruce Y. Lee, Forbes.com, 21 July 2026 Only one type of JIA, polyarticular arthritis positive for IgM rheumatoid factor, is believed to be the same disease as adult RA. Lana Barhum, Verywell Health, 5 June 2024 One of these blood tests measures the amount of rheumatoid factor (RF), a protein produced by your immune system that can attack healthy tissue, in your body. Women's Health, 4 Apr. 2023 Nearly everyone who is evaluated for psoriatic arthritis will have their blood tested for rheumatoid factor (RF), a protein produced by the immune system that attacks healthy joints. Sara Gaynes Lev, SELF, 30 July 2021

Word History

First Known Use

1949, in the meaning defined above

Time Traveler
The first known use of rheumatoid factor was in 1949

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Cite this Entry

“Rheumatoid factor.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/rheumatoid%20factor. Accessed 30 Jul. 2026.

Medical Definition

rheumatoid factor

noun
: an autoantibody of high molecular weight that reacts against immunoglobulins of the class IgG and is often present in rheumatoid arthritis

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