prefrontal cortex

noun

: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning

Examples of prefrontal cortex in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
That’s because problem-solving, logical planning and abstract thinking are all carried out by a key region of the brain known as the prefrontal cortex, which is notoriously inflexible. David Cox, NBC news, 4 June 2026 These areas included the prefrontal cortex, cingulate cortex, parietal and temporal cortices, and the amygdala, which are involved in pain processing, emotional regulation, and cognition. Stephanie Anderson Witmer, Health, 2 June 2026 Early relational experiences shape the brain's regulatory systems—particularly within the prefrontal cortex. Sharon A. Kuhn, Forbes.com, 28 May 2026 Their prefrontal cortex works more efficiently, suggesting the trait is neurological rather than a skill anyone can develop through practice. Allison Palmer, Charlotte Observer, 27 May 2026 See All Example Sentences for prefrontal cortex

Word History

First Known Use

1892, in the meaning defined above

Time Traveler
The first known use of prefrontal cortex was in 1892

Browse Nearby Words

Cite this Entry

“Prefrontal cortex.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/prefrontal%20cortex. Accessed 12 Jun. 2026.

Medical Definition

prefrontal cortex

noun
: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

More from Merriam-Webster