prefrontal

1 of 2

adjective

pre·​fron·​tal (ˌ)prē-ˈfrən-tᵊl 

: anterior to or involving the anterior part of a frontal structure

a prefrontal bone

prefrontal

2 of 2

noun

: a prefrontal part (such as a bone)

Examples of prefrontal in a Sentence

Recent Examples on the Web

Adjective

The technology-bilingualism argument is neurologically grounded and observationally compelling, but the causal chain from prefrontal developmental timing to technological rupture to career outcomes has not been formally tested. — Nick Lichtenberg, Fortune, 3 July 2026

Researchers have shown that when something about an environment is familiar and aligns with your prior experiences, the prefrontal regions of your brain – those responsible for executive functions such as decision-making – become more active. — Paulina Maxim, The Conversation, 11 May 2026

Noun

And when people refused to profit from harming others, the prefrontal cortex increased its communication with the striatum. — Molly Crockett, Scientific American Blog Network, 15 May 2017

During the adolescent years the prefrontal cortex, the portion of your brain that sits just behind your forehead, is still forming. — Molly Lotz, The Denver Post, 14 Apr. 2017

Word History

First Known Use

Adjective

1851, in the meaning defined above

Noun

1851, in the meaning defined above

Phrases Containing prefrontal

• prefrontal cortex

Rhymes for prefrontal

• frontal
• orbitofrontal

Medical Definition

prefrontal

adjective

pre·​fron·​tal ˌprē-ˈfrənt-ᵊl 

1

: situated or occurring anterior to a frontal structure

a prefrontal bone

2

: of, relating to, or constituting the prefrontal lobe or prefrontal cortex of the brain