pre·fron·tal
(ˌ)prē-ˈfrən-tᵊl 
: anterior to or involving the anterior part of a frontal structure
a prefrontal bone
: a prefrontal part (such as a bone)
Examples of prefrontal in a Sentence
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Anna Barnhill, Forbes.com, 13 Aug. 2025
And the technology had to pick up subtle electrical activity emanating from the brain’s prefrontal lobe, the hub of reasoning, decision making, and information processing—signals that are far weaker than those generated by the heart.
—IEEE Spectrum, 29 May 2025
Christof Koch, Scientific American, 1 Dec. 2019
When corrected to brain size, the domesticated rabbits' amygdala's were roughly 9-10% smaller, while their medial prefrontal cortices were about 11-12% bigger.
—Christie Wilcox, Discover Magazine, 27 June 2018
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Adjective
This activates prefrontal regions while reducing amygdala reactivity, creating optimal conditions for bias-free decisions.
—Anna Barnhill, Forbes.com, 13 Aug. 2025
And the technology had to pick up subtle electrical activity emanating from the brain’s prefrontal lobe, the hub of reasoning, decision making, and information processing—signals that are far weaker than those generated by the heart.
—IEEE Spectrum, 29 May 2025
Noun
Dehaene and Changeux postulated that the workspace is instantiated by a network of pyramidal (excitatory) neurons linked to far-flung cortical regions, in particular the prefrontal, parietotemporal and midline (cingulate) associative areas.
—Christof Koch, Scientific American, 1 Dec. 2019
When corrected to brain size, the domesticated rabbits' amygdala's were roughly 9-10% smaller, while their medial prefrontal cortices were about 11-12% bigger.
—Christie Wilcox, Discover Magazine, 27 June 2018
See All Example Sentences for prefrontal
Cite this Entry
“Prefrontal.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/prefrontal. Accessed 30 Sep. 2025.
Copy CitationMedical Definition
prefrontal
adjective
pre·fron·tal
ˌprē-ˈfrənt-ᵊl
1
: situated or occurring anterior to a frontal structure
a prefrontal bone
2
: of, relating to, or constituting the prefrontal lobe or prefrontal cortex of the brain
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