1
: of, relating to, or being muscular contraction in the absence of significant resistance, with marked shortening of muscle fibers, and without great increase in muscle tone compare isometric
2
: isosmotic
used of solutions

Examples of isotonic in a Sentence

Recent Examples on the Web
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Sets were littered with ice coolers and sachets of isotonic powder. Charlie Campbell, TIME, 24 Jan. 2025 Cleansing with paint thinner and isotonic saline solution was necessary. Discover Magazine, 19 Nov. 2019

Word History

Etymology

International Scientific Vocabulary

First Known Use

1891, in the meaning defined at sense 1

Time Traveler
The first known use of isotonic was in 1891

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Cite this Entry

“Isotonic.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/isotonic. Accessed 31 Jul. 2026.

Medical Definition

isotonic

adjective
1
: of, relating to, or exhibiting equal osmotic pressure
isotonic solutions
compare hypertonic sense 2, hypotonic sense 2
2
: of, relating to, or being muscular contraction in the absence of significant resistance, with marked shortening of muscle fibers, and without great increase in muscle tone compare isometric sense 2
isotonicity noun
plural isotonicities
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