Medical Dictionary

histone deacetylase

noun

medical Definition of histone deacetylase

:an enzyme that catalyzes the hydrolysis of acetyl groups from histone
  • Histones are proteins that regulate DNA packing, and histone deacetylases are enzymes that control the way those proteins work. One of their effects is to keep HIV genes switched off.
  • The Economist23 July 2011

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