glucagon-like peptide

noun

glu·​ca·​gon-like peptide

plural glucagon-like peptides

: either of two intestinal hormones secreted together when nutrients (such as carbohydrates and lipids) are present in the small intestine:

a

or glucagon-like peptide-1 : one that stimulates insulin secretion, inhibits glucagon secretion, slows the movement of stomach contents into the small intestine, and promotes feelings of satiety : glp-1

The small intestine releases a number of appetite-suppressing hormones that promote satiety, including glucagon-like peptide-1 …

—Samantha Murphy

b

or glucagon-like peptide-2 : one that stimulates cell proliferation in the intestinal mucosa and has little effect on insulin secretion : glp-2

Word History

First Known Use

1973, in the meaning defined above

Rhymes for glucagon-like peptide

• hydrochlorothiazide
• lipopolysaccharide
• mucopolysaccharide
• oligonucleotide
• abide
• allied
• applied
• aside
• astride
• azide
• backside
• bankside

Medical Definition

glucagon-like peptide

noun

: either of two intestinal hormones secreted together when nutrients (such as carbohydrates and lipids) are present in the small intestine:

a

or glucagon-like peptide 1 : one that stimulates insulin secretion and inhibits glucagon secretion, stomach emptying, and food intake

The Food and Drug Administration (FDA) has approved agents that increase blood glucagon-like peptide 1 … activity or levels and stimulate insulin secretion (in a glucose-dependent manner) while inhibiting glucagon secretion.

—Faramarz Ismail-Beigi, The New England Journal of Medicine

—abbreviation GLP-1

b

or glucagon-like peptide 2 : one that stimulates cell proliferation in the intestinal mucosa and has little effect on insulin secretion

—abbreviation GLP-2