Medical Dictionary

antineutrophil cytoplasmic antibody

noun an·ti·neu·tro·phil cytoplasmic antibody \ -ˈn(y)ü-trə-ˌfil- \
variants: also antineutrophilic cytoplasmic antibody play \-ˌn(y)ü-trə-ˈfil-ik\

medical Definition of antineutrophil cytoplasmic antibody

:any of a group of autoantibodies that bind to cytoplasmic regions of neutrophils and are associated with diseases (such as Wegener's granulomatosis, Churg-Strauss syndrome, and polyarteritis nodosa) characterized by inflammation of small blood vessels
  • A positive test for antineutrophil cytoplasmic antibody may be associated with a vasculitis of the skin …
  • —Barbara J. RutledgeSkin and Allergy NewsDecember 2007
  • … a test that seeks the antineutrophilic cytoplasmic antibody (ANCA), and is generally diagnostic of vasculitis, but not specific enough to be definitive.
  • —Robert G. Lahita and Ina L. YalofWomen and Autoimmune Disease: The Mysterious Ways Your Body Betrays Itself2004
abbreviation ANCA

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