Medical Dictionary

alternative splicing

variants: also

alternative RNA splicing

Medical Definition of alternative splicing

  1. :  a mechanism in which different combinations of exons are joined together during the final stages of transcription so that more than one messenger RNA is produced from a single gene In complex genes, alternative splicing can generate dozens or even hundreds of different mRNA isoforms from a single transcript.—Vivien Marx, Genomics & Proteomics, May 2004—called also differential splicing Alternative splicing produces different messenger RNAs especially through the removal of one or more exons. Since each messenger RNA produced forms a different protein product, this mechanism enables a gene to encode multiple proteins that are structurally and functionally distinct.

alternatively spliced


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a brief usually trivial fact

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