Medical Definition of Picornaviridae
: a family of small single-stranded RNA viruses that have an icosahedral virion with no envelope and that include the causative agents of avian encephalomyelitis, encephalomyocarditis, hepatitis A, polio, foot-and-mouth disease, and hand, foot and mouth disease—see coxsackievirus, echovirus, enterovirus, rhinovirus
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