Pelizaeus-Merzbacher disease

noun
Pel·​i·​zae·​us-Merz·​bach·​er disease | \ ˌpel-ēt-ˈsā-əs-ˈmerts-ˌbäḵ-ər- How to pronounce Pelizaeus-Merzbacher disease (audio) \

Medical Definition of Pelizaeus-Merzbacher disease

: a progressive disease of the central nervous system that is marked by myelin degeneration resulting in deterioration of cognitive and motor functioning

Note: Pelizaeus-Merzbacher disease is a leukodystrophy with symptoms including involuntary eye movement, delayed development (as of motor skills and language), weak muscle tone, impaired coordination, and spasticity. It is inherited as an X-linked recessive trait requiring that both parents pass on a copy of the defective gene on the X chromosome.

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