leu·​ko·​dys·​tro·​phy | \ ˌlü-kō-ˈdi-strə-fē How to pronounce leukodystrophy (audio) \
plural leukodystrophies

Definition of leukodystrophy

: any of several genetically determined diseases characterized by progressive degeneration of myelin in the brain, spinal cord, and peripheral nerves

Examples of leukodystrophy in a Sentence

Recent Examples on the Web Metachromatic leukodystrophy, or MLD, is a rare, hereditary disease that leads to premature death. Priscilla Totiyapungprasert, The Arizona Republic, 5 Sep. 2020 Metachromatic leukodystrophy is the result of a genetic mutation, and leads to a breakdown of the protective covering around nerve cells and nerve fibers, known as myelin. Lisa Schencker, chicagotribune.com, 15 Nov. 2019 More recently, Evelyn Chizzo had been diagnosed with leukodystrophy, which is a rare genetic disease that affects the brain and nervous system. Rich Mayor, chicagotribune.com, 5 Oct. 2019 Pennsylvania is one of the few states in the U.S. where someone diagnosed with metachromatic leukodystrophy gets fast-tracked for Medicaid. Maria Kefalas, STAT, 2 Dec. 2019 The four-year-old has a rare disease called metachromatic leukodystrophy that could rob him of the ability to walk, sit and hold up his own head within the next year. Chicago Tribune Staff, chicagotribune.com, 18 Nov. 2019 After further testing, he was diagnosed with metachromatic leukodystrophy in July of this year. Lisa Schencker, chicagotribune.com, 15 Nov. 2019 Doctors knew Massimo suffered from a type of leukodystrophy, a genetic disorder of the central nervous system that destroys the brain’s white matter. Wired, 30 Aug. 2019 Ollie passed away in December due to a rare genetic disorder, leukodystrophy, which affects the neural anatomy of a person in a variety of ways. Joe Mario Pedersen, orlandosentinel.com, 5 July 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'leukodystrophy.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of leukodystrophy

1960, in the meaning defined above

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The first known use of leukodystrophy was in 1960

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Cite this Entry

“Leukodystrophy.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/leukodystrophy. Accessed 27 Jan. 2022.

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More Definitions for leukodystrophy


variants: or chiefly British leucodystrophy \ ˌlü-​kō-​ˈdis-​trə-​fē How to pronounce leukodystrophy (audio) \
plural leukodystrophies

Medical Definition of leukodystrophy

: any of several inherited diseases (as adrenoleukodystrophy) characterized by progressive degeneration of myelin in the brain, spinal cord, and peripheral nerves


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