Medical Dictionary

McArdle's disease

noun Mc·Ar·dle's disease \ mək-ˈärd-ᵊlz- \

medical Definition of McArdle's disease

: a glycogen storage disease that is inherited as an autosomal recessive trait, is marked especially by muscle weakness and myoglobinuria, and is caused by deficiency of a phosphorylase normally present in skeletal muscle called also McArdle's syndrome

Biographical Note for mcardle's disease

McArdle, Brian (1911–2002), British physician. McArdle served on the staff of the department of chemical pathology at a London hospital. He was the author of articles on diseases of the muscle. In 1951 he published a paper on myopathy due to a defect in muscle glycogen breakdown. His report was based on the study of a 30-year-old male who had had the disease since childhood.

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