Donohue syndrome


Don·​o·​hue syndrome ˈdän-ə-ˌhyü- How to pronounce Donohue syndrome (audio)
variants also Donohue's syndrome
: a rare hereditary disorder of extreme insulin resistance that is characterized especially by intrauterine and postnatal growth retardation, skin abnormalities, hirsutism, emaciation, widely spaced eyes, thick lips, low-set ears, and enlarged genitalia and is usually fatal during early infancy : leprechaunism

Note: Donohue syndrome is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

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Cite this Entry

“Donohue syndrome.” Medical Dictionary, Merriam-Webster, Accessed 23 Sep. 2023.

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