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This can happen after vomiting, diarrhea, heavy sweating, or taking medicines like diuretics (water pills) or laxatives.—Lindsay Curtis, Verywell Health, 19 Feb. 2026 Many water pills also lower potassium.—Merve Ceylan, Health, 22 Nov. 2025 Your medications could be a factor Certain medications, especially diuretics (water pills) prescribed for high blood pressure or heart conditions, can significantly increase nighttime urination by boosting urine output.—Dr. Jamin Brahmbhatt, CNN Money, 26 Mar. 2025 Diuretics, also known as water pills, are a class of drugs that increase urine production and help the body get rid of excess fluid and salt.—Mirna Alsharif, NBC News, 4 Mar. 2025