von Willebrand disease

noun (1)
von Wil·​le·​brand disease | \ vän-ˈvi-lə-ˌbränt- How to pronounce von Willebrand disease (audio) \
variants: or less commonly von Willebrand's disease \ vän-​ˈvi-​lə-​ˌbränts-​ How to pronounce von Willebrand's disease (audio) \

Definition of von Willebrand disease

 (Entry 1 of 13)

: a genetic blood disorder marked by prolonged, excessive, or abnormal bleeding that commonly results in recurrent nosebleeds, heavy menstrual flow, and bleeding from the gums, is caused by deficient or defective von Willebrand factor, and typically occurs in a mild form that is less serious than hemophilia

Note: Von Willebrand disease is inherited chiefly as an autosomal dominant trait in which only one parent must pass on a copy of the defective gene on a chromosome other than a sex chromosome.

von Willebrand factor

noun (2)

Definition of von Willebrand factor (Entry 2 of 13)

: a large glycoprotein clotting factor circulating in blood plasma that mediates platelet adhesion to collagen at sites of vascular injury, that binds to and protects factor VIII from degradation, and that is deficient or defective in individuals affected with von Willebrand disease

called also VW factor

Note: Von Willebrand factor is synthesized in endothelial cells of blood vessels and in megakaryocytes of bone marrow.

Baeyer, von

biographical name (1)
Bae·​yer, von | \ ˈbā-ər How to pronounce Baeyer, von (audio) \

Definition of Baeyer, von (Entry 3 of 13)

Adolf 1835–1917 German chemist

Hildegard von Bingen

biographical name (2)
Hil·​de·​gard von Bing·​en | \ ˈhil-də-ˌgärd-fȯn-ˈbiŋ-ən How to pronounce Hildegard von Bingen (audio) , -ˌgärt-\

Definition of Hildegard von Bingen (Entry 4 of 13)

1098–1179 German mystic and composer

Von Braun

biographical name (3)

Definition of Von Braun (Entry 5 of 13)

Wernher — see braun

Wagner von Jauregg

biographical name (4)
Wagner von Jau·​regg | \ -ˈyau̇-ˌrek How to pronounce Wagner von Jauregg (audio) \
variants: or Wagner-Jauregg

Definition of Wagner von Jauregg (Entry 6 of 13)

Julius 1857–1940 Austrian neurologist and psychiatrist

Walther von der Vogelweide

biographical name (5)
Wal·​ther von der Vo·​gel·​wei·​de | \ ˈväl-tər-ˌfȯn-dər-ˈfō-gəl-ˌvī-də How to pronounce Walther von der Vogelweide (audio) \

Definition of Walther von der Vogelweide (Entry 7 of 13)

circa 1170–circa 1230 German minnesinger and poet

Wolfram von Eschenbach

biographical name (6)
Wol·​fram von Esch·​en·​bach | \ ˈwu̇l-frəm-vän-ˈe-shən-ˌbäk How to pronounce Wolfram von Eschenbach (audio) , ˈvȯl-ˌfräm-, -ˌbäḵ\

Definition of Wolfram von Eschenbach (Entry 8 of 13)

circa 1170–circa 1220 German poet and minnesinger

law of von Baer

Definition of law of von Baer (Entry 9 of 13)

: von baer's law

von Baer's law

noun (3)
\ vä|nˈba(a)(ə)rz-, fə|, və|, -be(ə)rz-\

Definition of von Baer's law (Entry 10 of 13)

: a principle in biology: the development of an organism proceeds from the general to the special and embryos belonging to various classes closely resemble one another in their earlier stages but diverge more and more as development proceeds — compare recapitulation theory

von Behr trout

noun (4)
\ -ˈbe(ə)r-\

Definition of von Behr trout (Entry 11 of 13)

: a European brown trout (Salmo trutta)

von Monakow's tract

noun (5)
von Mo·​na·​kow's tract | \ -ˈmōnəˌkəfs-\

Definition of von Monakow's tract (Entry 12 of 13)

: a rubrospinal tract

von Pirquet's test

noun
von Pir·​quet's test | \ -(ˈ)pir¦kāz-\

Definition of von Pirquet's test (Entry 13 of 13)

: pirquet test

First Known Use of von Willebrand disease

Noun (1)

1941, in the meaning defined above

Noun (2)

1970, in the meaning defined above

History and Etymology for von Willebrand disease

Noun (1)

after Erik Adolf von Willebrand †1949 Finnish physician

Noun (2)

after Erik Adolf von Willebrand †1949 Finnish physician

Noun (3)

after Karl E. von Baer †1876 Estonian embryologist

Noun (4)

probably from the name von Behr

Noun (5)

after Konstantin von Monakow †1930 Russian neurologist

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The first known use of von Willebrand disease was in 1941

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von Willebrand disease

noun
von Wil·​le·​brand disease | \ -ˌbränt-\
variants: also von Willebrand's disease

Medical Definition of von Willebrand disease

: a genetic blood disorder marked by prolonged, excessive, or abnormal bleeding that commonly results in recurrent nosebleeds, heavy menstrual flow, and bleeding from the gums, is caused by deficient or defective von Willebrand factor, and typically occurs in a mild form that is less serious than hemophilia

Note: Von Willebrand disease is inherited chiefly as an autosomal dominant trait in which only one parent must pass on a copy of the defective gene on a chromosome other than a sex chromosome.

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