hemophilia

noun
he·​mo·​phil·​ia | \ ˌhē-mə-ˈfi-lē-ə How to pronounce hemophilia (audio) \

Definition of hemophilia

: a hereditary, sex-linked blood defect occurring almost exclusively in males that is marked by delayed clotting of the blood with prolonged or excessive internal or external bleeding after injury or surgery and in severe cases spontaneous bleeding into joints and muscles and that is caused by a deficiency of clotting factors

Note: Hemophilia is inherited as an X-linked recessive trait in which the mother must pass on a copy of the defective gene to a male child, and more rarely, both parents must pass on copies of the defective gene to a female child.

— see hemophilia a, hemophilia b

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Did You Know?

The dreaded disease known as hemophilia is the result of an inherited gene, and almost always strikes boys rather than girls (though mothers may pass the gene to their sons). Since the blood lacks an ingredient that causes it to clot or coagulate when a blood vessel breaks, even a minor wound can cause a hemophiliac to bleed to death if not treated. Bleeding can be particularly dangerous when it's entirely internal, with no visible wound, since the person may not be aware it's happening. Queen Victoria transmitted the hemophilia gene to royal families all across Europe; the hemophilia of a young Russian prince played a part in the downfall of the Russian czars. Today, hemophiliacs take drugs that stop the bleeding by speeding coagulation, and hemophiliac life expectancies in developed countries are almost as long as the average.

Examples of hemophilia in a Sentence

Recent Examples on the Web Drugs derived from plasma are used for treating ailments such as hemophilia and are showing promise in slowing the progression of Alzheimer’s. Emma Vickers, Bloomberg.com, "Family Builds $3.8 Billion Fortune, One Pint of Blood at a Time," 13 May 2020 It is designed for hemophilia patients to make the protein missing for blood-clotting. Jared S. Hopkins, WSJ, "BioMarin Explores Pricing Experimental Gene Therapy at $2 Million to $3 Million," 16 Jan. 2020 Plasma is transformed into a wide variety of therapies that benefit thousands of people every day suffering from conditions such as hemophilia and immune deficiencies. Dallas News, "The Power of Plasma: How Your Plasma Can Make a Difference," 5 Feb. 2020 Last year, two of the most significant growth drivers were Ocrevus, for multiple sclerosis, and Hemlibra, for hemophilia. Denise Roland, WSJ, "Cancer-Drug Giant Roche Posts Growth as Diversification Efforts Pay Off," 30 Jan. 2020 The company also wrote down the value of hemophilia treatment Eloctate by €1.2 billion. Denise Roland, WSJ, "Zantac Recall Weighs on Sanofi’s Earnings," 6 Feb. 2020 The Spark holdup confused the market because there are multiple other drugmakers developing hemophilia gene therapies. Washington Post, "Roche’s Small Spark Deal Holds a Big Regulatory Warning," 17 Dec. 2019 But a study of dogs with hemophilia, treated with AAV up to 10 years earlier, has shown that the vector can readily insert its payload into the host’s DNA near genes that control cell growth. Jocelyn Kaiser, Science | AAAS, "Virus used in gene therapies may pose cancer risk, dog study hints," 6 Jan. 2020 Regulators needed to be persuaded that Roche wasn’t just buying Spark and its hemophilia A treatment, currently in clinical studies, to thwart a potential competitor for Roche’s existing hemophilia drug. BostonGlobe.com, "Chief executive Sumit Singh," 26 Dec. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'hemophilia.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of hemophilia

1872, in the meaning defined above

History and Etymology for hemophilia

New Latin

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Time Traveler for hemophilia

Time Traveler

The first known use of hemophilia was in 1872

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Statistics for hemophilia

Cite this Entry

“Hemophilia.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hemophilia. Accessed 23 Nov. 2020.

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More Definitions for hemophilia

hemophilia

noun
How to pronounce hemophilia (audio)

English Language Learners Definition of hemophilia

medical : a serious disease that causes a person who has been cut or injured to keep bleeding for a very long time

hemophilia

noun
he·​mo·​phil·​ia
variants: or chiefly British haemophilia \ ˌhē-​mə-​ˈfil-​ē-​ə How to pronounce haemophilia (audio) \

Medical Definition of hemophilia

: a tendency to uncontrollable bleeding especially : a hereditary, sex-linked blood disorder occurring almost exclusively in males that is marked by delayed clotting of the blood with prolonged or excessive internal or external bleeding after injury or surgery and in severe cases spontaneous bleeding into joints and muscles and that is caused by a deficiency of clotting factors

Note: Hemophilia is inherited as an X-linked recessive trait in which the mother must pass on a copy of the defective gene to a male child, and more rarely, both parents must pass on copies of the defective gene to a female child.

— see hemophilia a, hemophilia b — compare von willebrand disease

More from Merriam-Webster on hemophilia

Nglish: Translation of hemophilia for Spanish Speakers

Britannica.com: Encyclopedia article about hemophilia

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