var·​i·​ole | \ˈverēˌōl, ˈva(a)r-\
plural -s

Definition of variole 

1 : foveola

2 : a spherule of a variolite

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First Known Use of variole

1826, in the meaning defined at sense 1

History and Etymology for variole

Medieval Latin variola pustule, pox

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The first known use of variole was in 1826

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