trazodone

noun

traz·​o·​done ˈtra-zə-ˌdōn 

: an antidepressant drug C₁₉H₂₂ClN₅O administered in the form of its hydrochloride

Examples of trazodone in a Sentence

Recent Examples on the Web

Holding up a colorful chart, Reddington walked jurors through more than a dozen prescriptions written by Clancy’s psychiatrist, including Ativan, Zoloft, Valium, trazodone and buspirone. — Althea Legaspi, Rolling Stone, 27 Aug. 2026

No dosage of melatonin, Ambien, or trazodone, and no quantity of alcohol. — Weike Wang, New Yorker, 17 May 2026

By the end of January 2023, Lindsay had been prescribed a series of drugs, including Zoloft, trazodone, Prozac, Ambien, Remeron, Klonopin, and Seroquel. — Colleen Cronin, Boston Herald, 22 Jan. 2026

Sleep medications — such as the antidepressants doxepin or trazodone or certain nonbenzodiazepine hypnotics — can be helpful short-term, Kaylor said. — Kristen Rogers, CNN Money, 20 Nov. 2025

Your physician may also be able to prescribe an alternative treatment such as clonidine or trazodone. — C. Michael White, The Conversation, 7 Nov. 2025

Some medications may make trazodone less effective. — Jessica Swirble, Verywell Health, 17 Sep. 2025

Berry additionally said Dale had less than a therapeutic dose of trazodone in his system, and that a combination of it and alcohol could suppress a person’s respiratory system. — Teri Figueroa, Mercury News, 4 Sep. 2025

The Cleveland Clinic lists trazodone, amitriptyline, clomipramine doxepin, fluoxetine, sertraline, phenelzine and rasagiline as possible culprits. — Bruce Y. Lee, Forbes.com, 15 May 2025

Word History

Etymology

perhaps from International Scientific Vocabulary triazo azido + pyridine + -one

First Known Use

1971, in the meaning defined above

Rhymes for trazodone

• acetone
• anglophone
• baritone
• bourguignon
• buspirone
• chaperon
• chaperone
• cobblestone
• collarbone
• cornerstone
• cortisone
• dictaphone

Medical Definition

trazodone

noun

traz·​o·​done ˈtraz-ə-ˌdōn 

: an antidepressant drug that is administered in the form of its hydrochloride C₁₉H₂₂ClN₅O·HCl and inhibits the uptake of serotonin by the brain