synthetase

noun

syn·​the·​tase ˈsin-thə-ˌtās How to pronounce synthetase (audio)
-ˌtāz
: an enzyme that catalyzes the linking together of two molecules usually using the energy derived from the concurrent splitting off of a pyrophosphate group from a triphosphate (such as ATP)

called also ligase

Examples of synthetase in a Sentence

Recent Examples on the Web To find out, the team compared Klosneuvirus’s aminoacyl tRNA synthetase sequences with other forms of the enzymes across the tree of life. Jeffrey Marlow, Discover Magazine, 20 Apr. 2017 The results were all over the place, with each synthetase showing closest similarity to a different organism (mostly algae). Jeffrey Marlow, Discover Magazine, 20 Apr. 2017 For example, most viruses lack aminoacyl tRNA synthetase enzymes, which shuttle amino acids onto transfer RNA molecules; these in turn make their way to the ribosome, dropping off their cargo to build proteins from the chains of amino acids. Jeffrey Marlow, Discover Magazine, 20 Apr. 2017

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'synthetase.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

synthetic + -ase

First Known Use

1947, in the meaning defined above

Time Traveler
The first known use of synthetase was in 1947

Dictionary Entries Near synthetase

Cite this Entry

“Synthetase.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/synthetase. Accessed 27 May. 2024.

Medical Definition

synthetase

noun
syn·​the·​tase ˈsin-thə-ˌtās, -ˌtāz How to pronounce synthetase (audio)
: an enzyme that catalyzes the linking together of two molecules especially by using the energy derived from the concurrent splitting off of a pyrophosphate group from a triphosphate (as ATP)

called also ligase

More from Merriam-Webster on synthetase

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