substance

noun

sub·​stance ˈsəb-stən(t)s 

1

a

: essential nature : essence

b

: a fundamental or characteristic part or quality

the substance of her speech

c

Christian Science : god sense 1b

2

a

: ultimate reality that underlies all outward manifestations and change

b

: practical importance : meaning, usefulness

The … bill—which will be without substance in the sense that it will authorize nothing more than a set of ideas …

—Richard Reeves

3

a

: physical material from which something is made or which has discrete existence

fabric of an unknown substance

b

: matter of particular or definite chemical constitution

a chemically pure substance

c

: something (such as drugs or alcoholic beverages) deemed harmful and usually subject to legal restriction

possession of a controlled substance

substance abuse

4

: material possessions : property

a family of substance

substanceless

ˈsəb-stən(t)s-ləs 

adjective

Phrases

in substance

: in respect to essentials : fundamentally

Synonyms of substance

• potential
• material
• potentiality
• making

Examples of substance in a Sentence

The pancreas secretes a substance called insulin.

The floor was covered with a white, powdery substance that turned out to be flour.

heroin and other illegal substances

He had a history of substance abuse.

When has he ever said anything of substance?

The results of the study give substance to their theory.

the substance of my argument

Recent Examples on the Web

Tagliabue implemented a policy on substance abuse that was considered the strongest in all major sports. —NPR, 9 Nov. 2025

But don’t mistake sweetness and spice for lack of substance. —Emilia Emerson, PEOPLE, 9 Nov. 2025

He was suspended to begin the 1995 season for cocaine and admitted to having a substance abuse problem. —Ryan Morik, FOXNews.com, 8 Nov. 2025

That strategy will include connecting people to services and, in some cases, mandating treatment for mental illnesses and substance use. —Elliott Wenzler, Denver Post, 8 Nov. 2025

Word History

Etymology

Middle English, from Anglo-French, from Latin substantia, from substant-, substans, present participle of substare to stand under, from sub- + stare to stand — more at stand

First Known Use

14th century, in the meaning defined at sense 1a

Phrases Containing substance

• a man/woman/person of substance
• be without substance
• controlled substance
• ground substance
• queen substance
• substance P
• sum and substance
• working substance

Kids Definition

substance

noun

sub·​stance ˈsəb-stən(t)s 

1

a

: essential nature : essence

divine substance

b

: the fundamental or essential part, quality, or meaning

the substance of the speech

2

a

: physical material from which something is made

b

: material of particular or definite chemical constitution

an oily substance

c

: something (as drugs or alcoholic beverages) considered harmful and usually subject to legal restriction

substance abuse

3

: material possessions : property

a person of substance

Medical Definition

substance

noun

sub·​stance ˈsəb-stən(t)s 

1

: physical material from which something is made or which has discrete existence

the substance of nerve tissue

2

: matter of particular or definite chemical constitution

3

: something (as alcohol, methamphetamine, or marijuana) deemed harmful and usually subject to legal restriction

heroin is a controlled substance

substance abuse

Legal Definition

substance

noun

sub·​stance

1

: substantive law

was a question of substance and not process

compare procedure

2

: something (as language) essential especially to establishing a valid right, claim, or charge

a title defective in form, not substance