significative

adjective
sig·nif·i·ca·tive | \sig-ˈni-fə-ˌkā-tiv \

Definition of significative 

2 : indicative symptoms significative of malaria

First Known Use of significative

1597, in the meaning defined at sense 2

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The first known use of significative was in 1597

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a state of commotion or excitement

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