significative

adjective
sig·​nif·​i·​ca·​tive | \ sig-ˈni-fə-ˌkā-tiv How to pronounce significative (audio) \

Definition of significative

2 : indicative symptoms significative of malaria

First Known Use of significative

1597, in the meaning defined at sense 2

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The first known use of significative was in 1597

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“Significative.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/significative. Accessed 19 Feb. 2020.

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Britannica English: Translation of significative for Arabic Speakers

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