side effect

noun

Synonyms of side effectnext
: a secondary and usually adverse effect (as of a drug)
toxic side effects

called also side reaction

Examples of side effect in a Sentence

Nausea and diarrhea are the side effects of the drug. the harmful side effects of using chemicals to kill insects The merger created positive side effects for both companies.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Her only side effect was fatigue. Kerry Breen, CBS News, 7 Mar. 2026 This side effect, which happens in the liver, may lead to unwanted weight gain. Kirsten Nunez, Martha Stewart, 7 Mar. 2026 Leucovorin is a form of folic acid used to reduce side effects from some chemotherapy drugs and treat folate deficiency. Liz Neporent, ABC News, 6 Mar. 2026 As Ozempic use becomes more and more prevalent in people’s lives, so does dealing with all of its side effects. Audrey Noble, Vogue, 6 Mar. 2026 See All Example Sentences for side effect

Word History

First Known Use

1814, in the meaning defined above

Time Traveler
The first known use of side effect was in 1814

Browse Nearby Words

Cite this Entry

“Side effect.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/side%20effect. Accessed 9 Mar. 2026.

Kids Definition

side effect

noun
: an often harmful and unwanted effect (as of a drug) that occurs along with the basic desired effect
the environmental side effects of using chemicals to kill pests

Medical Definition

side effect

noun
: a secondary and usually adverse effect (as of a drug)
toxic side effects
a side effect of drowsiness caused by antihistamines

called also side reaction

Last Updated: - Updated example sentences
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