ser·​tra·​line | \ ˈsər-trə-ˌlēn How to pronounce sertraline (audio) \

Definition of sertraline

: an antidepressant drug C17H17NCl2 administered in the form of its hydrochloride and acting to enhance serotonin activity

Examples of sertraline in a Sentence

Recent Examples on the Web Only people taking maintenance dosages of four antidepressants were included in the study: citalopram (Celexa), fluoxetine (Prozac), sertraline (Zoloft), and mirtazapine (Remeron). Sandee Lamotte, CNN, 30 Sep. 2021 Among her medications, both aripiprazole (Abilify) and sertraline (Zoloft) are less likely to cause weight gain than others in their class, but may still cause weight gain in some individuals. Dr. Keith Roach, oregonlive, 17 Aug. 2021 After a panic attack at an airport, Goode was referred to a psychiatrist, who put her on a low dose of Zoloft (sertraline, an SSRI antidepressant medication). Claire Gillespie,, 6 Nov. 2020 The same shortages were reported among companies that make sertraline. Erika Edwards, NBC News, 3 June 2020 Zoloft, which is sold under the generic name sertraline, was first approved in the United States in 1991., 2 June 2020 Its program also offers some free prescriptions, including metformin, medications used to treat high blood pressure and sertraline, which is generic for Zoloft and used to treat depression. Susan Selasky, Detroit Free Press, 17 Jan. 2020 Examples of such medications are fluoxetine, sertraline and citalopram. Arash Javanbakht, The Conversation, 18 Oct. 2019 Jason died from the combined effects of clonazepam, cocaine, sertraline, fentanyl, oxycodone and heroin. Emily Brindley,, 14 Oct. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'sertraline.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of sertraline

1983, in the meaning defined above

History and Etymology for sertraline

perhaps from serotonin + tetrahydro (combined with four atoms of hydrogen) + naphthalene + amine

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The first known use of sertraline was in 1983

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Cite this Entry

“Sertraline.” Dictionary, Merriam-Webster, Accessed 28 Jan. 2022.

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More Definitions for sertraline


ser·​tra·​line | \ ˈsər-trə-ˌlēn How to pronounce sertraline (audio) \

Medical Definition of sertraline

: a drug that functions as an SSRI and is administered orally in the form of its hydrochloride C17H17NCl2·HCl especially to treat depression, anxiety, panic disorder, and obsessive-compulsive disorder

Note: Sertraline is marketed under the trademark Zoloft.


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