ser·​tra·​line ˈsər-trə-ˌlēn How to pronounce sertraline (audio)
: an antidepressant drug C17H17NCl2 administered in the form of its hydrochloride and acting to enhance serotonin activity

Examples of sertraline in a Sentence

Recent Examples on the Web In an analogous human study in 2016, researchers in Brazil divided 57 adults taking the antidepressant sertraline for moderate to severe depression into two groups: one attended four sessions of aerobic activity a week for 28 days, and the other did not exercise. Ferris Jabr, Scientific American, 1 Jan. 2017 Recently, Etkin and a team of researchers developed an algorithm that used EEG data to predict how patients would respond to a common antidepressant medication called sertraline. Hannah Thomasy, Discover Magazine, 6 Dec. 2021 This is where sertraline and bepridil step in, according to Johansen and her co-authors. K. N. Smith, Discover Magazine, 3 June 2015 The sertraline was there to target the siRNA at specific cell types. Neuroskeptic, Discover Magazine, 4 Aug. 2011 The authors took an antidepressant, sertraline, and chemically welded it to a small interfering RNA (siRNA). Neuroskeptic, Discover Magazine, 4 Aug. 2011 Only people taking maintenance dosages of four antidepressants were included in the study: citalopram (Celexa), fluoxetine (Prozac), sertraline (Zoloft), and mirtazapine (Remeron). Sandee Lamotte, CNN, 30 Sep. 2021 Among her medications, both aripiprazole (Abilify) and sertraline (Zoloft) are less likely to cause weight gain than others in their class, but may still cause weight gain in some individuals. Dr. Keith Roach, oregonlive, 17 Aug. 2021 After a panic attack at an airport, Goode was referred to a psychiatrist, who put her on a low dose of Zoloft (sertraline, an SSRI antidepressant medication). Claire Gillespie,, 6 Nov. 2020 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'sertraline.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


perhaps from serotonin + tetrahydro (combined with four atoms of hydrogen) + naphthalene + amine

First Known Use

1983, in the meaning defined above

Time Traveler
The first known use of sertraline was in 1983

Dictionary Entries Near sertraline

Cite this Entry

“Sertraline.” Dictionary, Merriam-Webster, Accessed 4 Oct. 2023.

Medical Definition


ser·​tra·​line ˈsər-trə-ˌlēn How to pronounce sertraline (audio)
: a drug that functions as an SSRI and is administered orally in the form of its hydrochloride C17H17NCl2·HCl especially to treat depression, anxiety, panic disorder, and obsessive-compulsive disorder

Note: Sertraline is marketed under the trademark Zoloft.

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!