re·​up·​take | \ (ˈ)rē-ˈəp-ˌtāk How to pronounce reuptake (audio) \

Definition of reuptake

: the reabsorption by a neuron of a neurotransmitter following the transmission of a nerve impulse across a synapse

Examples of reuptake in a Sentence

Recent Examples on the Web Currently, almost all patients with depression are first treated with medications called selective serotonin reuptake inhibitors, a class of drugs that includes both Zoloft and Prozac. Claudia López Lloreda, STAT, 17 Aug. 2021 For one, psychedelics (with the exception of MDMA) lock onto serotonin receptors in the brain known as 5-HT2A (more specific than those targeted by antidepressant medicines such as selective serotonin reuptake inhibitors). Meryl Davids Landau, Good Housekeeping, 10 June 2021 Up to a third of people with the condition are still symptomatic 10 years after diagnosis, and the main therapeutic drugs of choice—the selective serotonin reuptake inhibitors sertraline and paroxetine—fail in up to 60% of patients. Jeffrey Kluger, Time, 11 May 2021 Serotonin helps regulate mood, and drugs known as selective serotonin reuptake inhibitors are widely prescribed and effective for treating chronic depression. Quanta Magazine, 27 Oct. 2020 The most common antidepressants, S.S.R.I’s (selective serotonin reuptake inhibitors), can flatten emotions. Maureen Stanton, Longreads, 10 Aug. 2020 Some medications, including serotonin reuptake inhibitors (SRIs), can be effective at controlling obsessive thoughts for the estimated 2 to 3 million adults with obsessive compulsive disorder. Marisa Cohen, Good Housekeeping, 23 Apr. 2020 The various selective serotonin-reuptake inhibitors used to treat depression offer a different challenge. The Economist, 14 Mar. 2020 My mother was taking opiates for her pain and Trazodone, a serotonin reuptake inhibitor, to manage her bipolar syndrome, before the surgery. Winston Ross, Longreads, 8 Dec. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'reuptake.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of reuptake

1968, in the meaning defined above

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The first known use of reuptake was in 1968

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Last Updated

23 Aug 2021

Cite this Entry

“Reuptake.” Dictionary, Merriam-Webster, Accessed 21 Oct. 2021.

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More Definitions for reuptake


re·​up·​take | \ (ˈ)rē-ˈəp-ˌtāk How to pronounce reuptake (audio) \

Medical Definition of reuptake

: the reabsorption by a neuron of a neurotransmitter following the transmission of a nerve impulse across a synapse antidepressants which block the reuptake of norepinephrine


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