re·​up·​take | \ (ˈ)rē-ˈəp-ˌtāk How to pronounce reuptake (audio) \

Definition of reuptake

: the reabsorption by a neuron of a neurotransmitter following the transmission of a nerve impulse across a synapse

Examples of reuptake in a Sentence

Recent Examples on the Web The most common antidepressants, S.S.R.I’s (selective serotonin reuptake inhibitors), can flatten emotions. Maureen Stanton, Longreads, "Through a Glass, Tearfully," 10 Aug. 2020 Some medications, including serotonin reuptake inhibitors (SRIs), can be effective at controlling obsessive thoughts for the estimated 2 to 3 million adults with obsessive compulsive disorder. Marisa Cohen, Good Housekeeping, "How to Help Someone With Obsessive Compulsive Disorder," 23 Apr. 2020 The various selective serotonin-reuptake inhibitors used to treat depression offer a different challenge. The Economist, "Pharmacogenomics can show what your body makes of a drug," 14 Mar. 2020 My mother was taking opiates for her pain and Trazodone, a serotonin reuptake inhibitor, to manage her bipolar syndrome, before the surgery. Winston Ross, Longreads, "What Shattered My Mother’s Mind," 8 Dec. 2019 These days, about 5 percent of expectant mothers use antidepressants, most commonly, serotonin reuptake inhibitors, or SSRIs, such as citalopram (brand name Celexa), paroxetine (Paxil), or sertraline (Zoloft). Julia Belluz, Vox, "We’re beginning to learn how moms’ antidepressants can affect fetuses," 9 Apr. 2018 And then, in the late 1980s there’s the arrival of serotonin reuptake inhibitors, known as SSRIs, and their promise to be different from the antidepressants of the past. Maggie Jones, New York Times, "A Reckoning With an Imperfect Science in ‘Blue Dreams’," 3 Apr. 2018 SSRIs work by blocking the reabsorption (reuptake) of serotonin in the brain, according to the Mayo Clinic. Martine Thompson, SELF, "8 Things You Should Know Before Going on Antidepressants for the First Time," 30 Mar. 2018 These also work to prevent the reuptake of GABA by neurons, prolonging the effect. Christie Wilcox, Scientific American, "How a Wasp Turns Cockroaches into Zombies," 1 May 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'reuptake.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of reuptake

1968, in the meaning defined above

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The first known use of reuptake was in 1968

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Last Updated

22 Aug 2020

Cite this Entry

“Reuptake.” Dictionary, Merriam-Webster, Accessed 19 Oct. 2020.

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More Definitions for reuptake


re·​up·​take | \ (ˈ)rē-ˈəp-ˌtāk How to pronounce reuptake (audio) \

Medical Definition of reuptake

: the reabsorption by a neuron of a neurotransmitter following the transmission of a nerve impulse across a synapse antidepressants which block the reuptake of norepinephrine

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