re·​chal·​lenge | \ (ˌ)rē-ˈsər-tə-ˌfī \
plural rechallenges

Definition of rechallenge

 (Entry 1 of 2)

: a physiological or immunological challenge (see challenge entry 2 sense 4) made subsequent to a previous challenge: such as
a : the readministration of a drug or other substance suspected of causing a prior adverse reaction in order to determine a definitive link by observing the patient's reaction the necessity of rechallenge when no suitable alternative exists
b : the readministration of an antineoplastic agent to a previously treated patient rechallenge with cisplatin in relapsing ovarian cancer patients
c : the subsequent transfer of a disease-causing agent (such as a virus or tumor cell) into a living organism and especially an experimental animal following immunotherapy for the purpose of determining robustness of the immunological response mice rechallenged with respiratory syncytial virus tumor rechallenge


rechallenged; rechallenging; rechallenges

Definition of rechallenge (Entry 2 of 2)

transitive verb

: to challenge again But now a new breed of independent store is beginning to rechallenge the chains and discount online retailers.— Madhusmita Bora To his great joy he reappeared at the same hour, toward the going down of the sun, and rechallenged Wunzh to a trial of strength.— Helen A. Clarke specifically to readminister a physiological and especially an immunological challenge (see challenge entry 2 sense 4) to (an organism or cell) When a drug is suspected of causing an adverse but not life-threatening condition, the simplest way to get an answer is to rechallenge the patient with the drug under controlled conditions. — Abigail Zuger

First Known Use of rechallenge


1953, in the meaning defined above


1950, in the meaning defined above

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The first known use of rechallenge was in 1950

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re·​chal·​lenge | \ (ˈ)rē-ˈchal-ənj \

Medical Definition of rechallenge

: a physiological or immunological challenge made subsequent to a previous challenge

Other Words from rechallenge

rechallenge transitive verb rechallenged; rechallenging

Comments on rechallenge

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a servile follower or underling

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