1

rechallenge

noun re·chal·lenge \ (ˌ)rē-ˈsər-tə-ˌfī \
|Updated on: 12 Jun 2018

Definition of rechallenge

plural rechallenges
medical
: a physiological or immunological challenge (see 2challenge 4) made subsequent to a previous challenge: such as
a : the readministration of a drug or other substance suspected of causing a prior adverse reaction in order to determine a definitive link by observing the patient's reaction
  • the necessity of rechallenge when no suitable alternative exists
b : the readministration of an antineoplastic agent to a previously treated patient
  • rechallenge with cisplatin in relapsing ovarian cancer patients
c : the subsequent transfer of a disease-causing agent (such as a virus or tumor cell) into a living organism and especially an experimental animal following immunotherapy for the purpose of determining robustness of the immunological response
  • mice rechallenged with respiratory syncytial virus
  • tumor rechallenge

First Known Use of rechallenge

1953

in the meaning defined above

See Words from the same year
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2

rechallenge

verb

Definition of rechallenge

rechallenged; rechallenging; rechallenges
: to challenge again
  • But now a new breed of independent store is beginning to rechallenge the chains and discount online retailers.
  • —Madhusmita Bora
  • To his great joy he reappeared at the same hour, toward the going down of the sun, and rechallenged Wunzh to a trial of strength.
  • —Helen A. Clarke
specifically to readminister a physiological and especially an immunological challenge (see 2challenge 4) to (an organism or cell)
  • When a drug is suspected of causing an adverse but not life-threatening condition, the simplest way to get an answer is to rechallenge the patient with the drug under controlled conditions.
  • —Abigail Zuger

First Known Use of rechallenge

1950

in the meaning defined above

See Words from the same year
NEW! Time Traveler

Medical Dictionary

rechallenge

noun re·chal·lenge \ (ˈ)rē-ˈchal-ənj \

medical Definition of rechallenge

: a physiological or immunological challenge made subsequent to a previous challenge

rechallenge

transitive verb rechallenged; rechallenging

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