: an intracellular form of a bacteriophage in which it is harmless to the host, is usually integrated into the hereditary material of the host, and reproduces when the host does

Examples of prophage in a Sentence

Recent Examples on the Web
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Once activated, the prophage cuts itself out of the bacterial genome, replicates and then packages its DNA into phages. — Quanta Magazine, 16 Oct. 2018 Known as a prophage, this stretch of foreign DNA can persist for generations before activating. — Quanta Magazine, 16 Oct. 2018 In the right conditions—say, if the bacteria are damaged, stressed, or exposed to certain conditions—prophages can awaken. — Beth Mole, Ars Technica, 1 Feb. 2018 But sometimes, a prophage gets trapped by a crippling mutation. — Ed Yong, Discover Magazine, 5 Jan. 2011 Within the bacterial genome, the viral DNA is called a prophage. — Ed Yong, Discover Magazine, 5 Jan. 2011

Word History

Etymology

pro- entry 1 + phage after French probactériophage, from pro- pro- entry 1 + bactériophage bacteriophage

Note: The French word probactériophage was introduced by André Lwoff and Antoinette Gutmann in "Recherches sur un Bacillus megatherium lysogène," Annales de l'Institut Pasteur, vol. 78, no. 6 (June, 1950), p. 734.

First Known Use

1951, in the meaning defined above

Time Traveler
The first known use of prophage was in 1951

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Cite this Entry

“Prophage.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/prophage. Accessed 1 Oct. 2026.

Medical Definition

: an intracellular form of a bacteriophage in which it is harmless to the host, is usually integrated into the hereditary material of the host, and reproduces when the host does

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