prodrug

noun
pro·​drug | \ ˈprō-ˌdrəg How to pronounce prodrug (audio) \
plural prodrugs

Definition of prodrug

: a pharmacologically inactive substance that is converted in the body (such as by enzymatic action) into a pharmacologically active drug … an enzyme that transforms an inactive drug molecule, or prodrug, into an active anticancer agent.Scientific American Cancer Smart One source of the variability is the metabolism of clopidogrel, which is a prodrug requiring biotransformation to generate its active metabolite.— Jessica L. Mega … an orally administered prodrug of ganciclovir that provides improved bioavailability.— Bernard A. Schwetz

First Known Use of prodrug

1968, in the meaning defined above

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The first known use of prodrug was in 1968

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Cite this Entry

“Prodrug.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/prodrug. Accessed 12 Jun. 2021.

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prodrug

noun
pro·​drug | \ ˈprō-ˌdrəg How to pronounce prodrug (audio) \

Medical Definition of prodrug

: a pharmacologically inactive substance that is the modified form of a pharmacologically active drug to which it is converted (as by enzymatic action) in the body One source of the variability is the metabolism of clopidogrel, which is a prodrug requiring biotransformation to generate its active metabolite.— Jessica L. Mega et al., The Journal of the American Medical Association, 27 Oct. 2010

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