pre·​clin·​i·​cal | \ (ˌ)prē-ˈkli-ni-kəl How to pronounce preclinical (audio) \

Definition of preclinical

1 : of, relating to, or concerned with the period preceding clinical manifestations
2 : of, relating to, or being the period in medical or dental education preceding the clinical study of medicine or dentistry
3 : occurring prior to clinical testing a preclinical animal study of a new therapy

Examples of preclinical in a Sentence

Recent Examples on the Web In addition to providing a list of all the kinds of preclinical work that scientists will have to accomplish before moving to human trials, the international commission also made recommendations for who would be eligible to participate in them. Megan Molteni, Wired, "Human Embryo Gene Editing Gets a Road Map—Not a Green Light," 3 Sep. 2020 The preclinical results at UAB will be used in an application for human trials. al, "Alabama research into nasal spray vaccine for coronavirus posts promising results," 25 Aug. 2020 In preclinical studies, the antibodies also recruit immune cells to help kill other cells already infected by the virus, Vir said. Matthew Herper, STAT, "Antibody drugs could be one of the best weapons against Covid-19. But will they matter?," 11 Aug. 2020 The institute also has not released any preclinical research involving animal models or experiments with cells raised in petri dishes. Nsikan Akpan, National Geographic, "Fauci ‘seriously doubts’ the Russia vaccine is ready for widespread use," 11 Aug. 2020 Steady and well-funded work to prove the CRISPR method, first with preclinical animal models then in clinical trials, is a moonshot for the present generation of biomedical scientists. Craig W. Stevens, The Conversation, "How gene editing a person’s brain cells could be used to curb the opioid epidemic," 5 Aug. 2020 That’s out of 21 vaccine candidates currently in clinical trials globally and another 139 in preclinical evaluation, according to the World Health Organization. Elizabeth Weise, USA TODAY, "'No one is safe until everyone is safe': Vaccine nationalism threatens global coronavirus effort," 12 July 2020 Earlier this week, there were 25 potential vaccines in clinical evaluation and 139 in preclinical evaluation, according to the WHO. Elaine Chen, WSJ, "Drugmakers Race to Build Covid-19 Vaccine Supply Chains," 30 July 2020 Several candidates are entering late stages of development According to the WHO, 21 candidates are in clinical trials and 139 are in preclinical evaluations. Devon Link, USA TODAY, "Fact Check: No, schools will not require a COVID-19 vaccine, with RFID chip, for students," 10 July 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'preclinical.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of preclinical

1876, in the meaning defined at sense 1

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The first known use of preclinical was in 1876

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Last Updated

8 Sep 2020

Cite this Entry

“Preclinical.” Dictionary, Merriam-Webster, Accessed 22 Sep. 2020.

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More Definitions for preclinical


pre·​clin·​i·​cal | \ (ˈ)prē-ˈklin-i-kəl How to pronounce preclinical (audio) \

Medical Definition of preclinical

1a : of, relating to, concerned with, or being the period preceding clinical manifestations the preclinical stage of diabetes mellitus
b : occurring prior to a clinical trial preclinical animal testing to assess a drug's safety
2 : of, relating to, or being the period in medical or dental education preceding the clinical study of medicine or dentistry the preclinical years specifically : of or relating to the early period of prescribed medical or dental study devoted to the basic sciences (as anatomy, physiology, and pathology) preclinical studies
3 : of, relating to, or being a science basic to medicine research in the preclinical sciences

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