preclinical

adjective

pre·​clin·​i·​cal (ˌ)prē-ˈkli-ni-kəl How to pronounce preclinical (audio)
1
: of, relating to, or concerned with the period preceding clinical manifestations
2
: of, relating to, or being the period in medical or dental education preceding the clinical study of medicine or dentistry
3
: occurring prior to clinical testing
a preclinical animal study of a new therapy

Examples of preclinical in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
But those preclinical studies uncovered how T cells, specialized white blood cells that are programmed to recognize and exterminate threats like cancer, are more active in the morning. Brenda Goodman, CNN Money, 6 Feb. 2026 In preclinical studies, ER-100 was delivered directly into the eye through intravitreal injection. Neetika Walter, Interesting Engineering, 4 Feb. 2026 Sinclair laid the foundation for his work using mice in preclinical trials, Life Biosciences then licensed the technology from Harvard and Sinclair’s lab to test on non-human primates to better match the human eye’s anatomy. Marco Quiroz-Gutierrez, Fortune, 30 Jan. 2026 After preclinical trials, there’s a human trial that’s smaller than the ones required for drugs, followed by a feasibility trial to confirm the device works as intended. Ana Castelain, Bloomberg, 28 Jan. 2026 See All Example Sentences for preclinical

Word History

First Known Use

1876, in the meaning defined at sense 1

Time Traveler
The first known use of preclinical was in 1876

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Cite this Entry

“Preclinical.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/preclinical. Accessed 20 Feb. 2026.

Medical Definition

preclinical

adjective
pre·​clin·​i·​cal (ˈ)prē-ˈklin-i-kəl How to pronounce preclinical (audio)
1
a
: of, relating to, concerned with, or being the period preceding clinical manifestations
the preclinical stage of diabetes mellitus
b
: occurring prior to a clinical trial
preclinical animal testing to assess a drug's safety
2
: of, relating to, or being the period in medical or dental education preceding the clinical study of medicine or dentistry
the preclinical years
specifically : of or relating to the early period of prescribed medical or dental study devoted to the basic sciences (as anatomy, physiology, and pathology)
preclinical studies
3
: of, relating to, or being a science basic to medicine
research in the preclinical sciences
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