pre·clin·i·cal | \(ˌ)prē-ˈkli-ni-kəl \

Definition of preclinical 

1 : of, relating to, or concerned with the period preceding clinical manifestations

2 : of, relating to, or being the period in medical or dental education preceding the clinical study of medicine or dentistry

3 : occurring prior to clinical testing a preclinical animal study of a new therapy

Examples of preclinical in a Sentence

Recent Examples on the Web

That day, panel members heard presentations on the drug's preclinical and clinical data from agency staff and AstraZeneca in Cambridge, U.K., its maker and one of the world's largest pharmaceutical companies. Charles Piller, Science | AAAS, "Hidden conflicts? Pharma payments to FDA advisers after drug approvals spark ethical concerns," 5 July 2018 In preclinical coursework, medical students learn in detail about obesity, diabetes, and the immense role diet plays in health and disease. Suhas Gondi, STAT, "Med schools need to get with the times on medical marijuana, chronic pain, and more," 24 Apr. 2018 There is growing evidence, however, that Alzheimer’s disease begins its attack on the brain many years before such symptoms appear, leading researchers to suggest that there is a syndrome called preclinical Alzheimer’s disease. Denise C. Park,, "5 myths about Alzheimer's disease," 18 June 2018 Each paper is based on preclinical research, and scientists said the findings were hardly a death knell for the nascent field of CRISPR. Damian Garde, STAT, "CRISPR scientists are in for the long haul. Wall Street is less patient," 11 June 2018 The money will go to adding staff and advancing drugs in preclinical programs to clinical trials. Bradley J. Fikes,, "San Diego biotech startup Escient raises $40 million," 9 May 2018 Two other versions are in preclinical development by Poseida. Bradley J. Fikes,, "Poseida raises $30.5 million for cancer cell therapy," 4 Apr. 2018 Of course, more often than not, products that seem exciting in preclinical work fail in subsequent rounds of testing. Amanda Schaffer, WIRED, "The Dying Scientist and His Rogue Vaccine Trial," 1 May 2018 In preclinical studies, the combination of epacadostat and immune checkpoint inhibitors was shown to be effective against cancer. Raymond J. Tesi, STAT, "Combination immunotherapy may have failed in the Incyte/Merck trial, but it’s here to stay," 23 Apr. 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'preclinical.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of preclinical

1876, in the meaning defined at sense 1

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Last Updated

13 Sep 2018

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The first known use of preclinical was in 1876

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pre·clin·i·cal | \(ˈ)prē-ˈklin-i-kəl \

Medical Definition of preclinical 

1a : of, relating to, concerned with, or being the period preceding clinical manifestations the preclinical stage of diabetes mellitus

b : occurring prior to a clinical trial preclinical animal testing to assess a drug's safety

2 : of, relating to, or being the period in medical or dental education preceding the clinical study of medicine or dentistry the preclinical years specifically : of or relating to the early period of prescribed medical or dental study devoted to the basic sciences (as anatomy, physiology, and pathology) preclinical studies

3 : of, relating to, or being a science basic to medicine research in the preclinical sciences

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