peyote

noun

pey·​o·​te pā-ˈō-tē 

variants or less commonly peyotl

pā-ˈō-tᵊl 

1

plural peyote or peyotes : a small, low, spineless cactus (Lophophora williamsii) of Mexico and southern Texas that has bluish- to grayish-green dome-shaped stems having jointed disk-shaped tubercles with tufts of woolly white hairs and that contains psychoactive alkaloids

Huichols speak of the peyote they gather as the flesh of deer, and of the tap root they customarily leave in the ground as its "bones," from which new plants will grow …

—Stacy B. Schaefer and Peter T. Furst

Peyote, a small, mescaline-laden cactus that grows in Mexico and Texas …

—The Wilson Quarterly

called also mescal

2

: a hallucinogenic drug containing mescaline that is derived from the dried disk-shaped tops of the peyote cactus and is used especially in the religious ceremonies of some Indigenous American peoples

In my childhood home, the word "medicine" is how we referred to peyote. … At a very young age, I understood the sacredness of this medicine …

—Dawn D. Davis

called also mescal

see also peyote button

Illustration of peyote

• peyote 1

Examples of peyote in a Sentence

Recent Examples on the Web

Another thing that a lot of these jam band fans love is drugs — tripping, smoking weed, rolling on MDMA, doing peyote or ayahuasca, and eventually many of them loved smoking crack and shooting heroin. —David Manheim, Rolling Stone, 19 Feb. 2026

British psychiatrist Humphry Osmond, who took part in a peyote ceremony with a First Nations group the Red Pheasant Band in Saskatchewan, Canada, in 1956, intuited the necessity of community, empathy, and ego renunciation during the psychedelic process. —Erica Rex, STAT, 19 Feb. 2026

Includes heroin, methaqualone, marijuana, LSD, peyote, ecstasy, and others. —Jenna Prestininzi, Freep.com, 19 Dec. 2025

The Native American Church, which is considered the largest Indigenous church in America and is located throughout the Southwest, has been legally using peyote, a hallucinogen, for services since the 1990s. —Pardis Mahdavi, The Conversation, 27 Aug. 2025

Word History

Etymology

Mexican Spanish peyote, from Nahuatl peyotl peyote cactus

First Known Use

1849, in the meaning defined at sense 2

Phrases Containing peyote

• peyote button

Kids Definition

peyote

noun

pey·​o·​te pā-ˈōt-ē 

1

: a drug containing mescaline that causes hallucinations and is obtained from the dried round and flattened tops of a small spineless cactus of the southwestern U.S. and Mexico

2

: the cactus from which peyote is obtained

called also mescal

Medical Definition

peyote

noun

pey·​o·​te pā-ˈōt-ē 

variants also peyotl

-ˈōt-ᵊl 

1

: a small, low, spineless cactus (Lophophora williamsii) of Mexico and southern Texas that has bluish- to grayish-green dome-shaped stems having jointed disk-shaped tubercles with tufts of woolly white hairs and that contains psychoactive alkaloids

called also mescal

2

: a hallucinogenic drug containing mescaline that is derived from the dried disk-shaped tops of the peyote cactus and is used especially in the religious ceremonies of some Indigenous American peoples

called also mescal

see also peyote button