peyote

noun

pey·​o·​te pā-ˈō-tē 

variants or less commonly peyotl

pā-ˈō-tᵊl 

1

plural peyote or peyotes : a small, low, spineless cactus (Lophophora williamsii) of Mexico and southern Texas that has bluish- to grayish-green dome-shaped stems having jointed disk-shaped tubercles with tufts of woolly white hairs and that contains psychoactive alkaloids

Huichols speak of the peyote they gather as the flesh of deer, and of the tap root they customarily leave in the ground as its "bones," from which new plants will grow …

—Stacy B. Schaefer and Peter T. Furst

Peyote, a small, mescaline-laden cactus that grows in Mexico and Texas …

—The Wilson Quarterly

called also mescal

2

: a hallucinogenic drug containing mescaline that is derived from the dried disk-shaped tops of the peyote cactus and is used especially in the religious ceremonies of some Indigenous American peoples

In my childhood home, the word "medicine" is how we referred to peyote. … At a very young age, I understood the sacredness of this medicine …

—Dawn D. Davis

called also mescal

see also peyote button

Illustration of peyote

• peyote 1

Examples of peyote in a Sentence

Recent Examples on the Web

Ruth Garbus can come across like the jazz singer at an elegant party who took peyote right before her set and just started freestyling. —Sam Sodomsky, Pitchfork, 16 June 2026

Supposedly the poem was inspired by a peyote-vision where the edifice of San Francisco’s Sir Francis Drake Hotel was transformed into a hideous, twisted, demonic visage, which inspired the beating heart of Howl’s second section. —Literary Hub, 3 June 2026

Book a scrub and massage with peyote balm at the spa, horse-riding lessons at the Equestrian Center, or explore nearby beach towns for a true taste of Nayarit’s sprawling coast. —Skyli Alvarez, Condé Nast Traveler, 17 May 2026

White people are even consuming psychedelics deeply associated with Indigenous culture, like peyote and ayahuasca. —Jerel Ezell, STAT, 1 May 2026

Word History

Etymology

Mexican Spanish peyote, from Nahuatl peyotl peyote cactus

First Known Use

1849, in the meaning defined at sense 2

Phrases Containing peyote

• peyote button

Kids Definition

peyote

noun

pey·​o·​te pā-ˈōt-ē 

1

: a drug containing mescaline that causes hallucinations and is obtained from the dried round and flattened tops of a small spineless cactus of the southwestern U.S. and Mexico

2

: the cactus from which peyote is obtained

called also mescal

Medical Definition

peyote

noun

pey·​o·​te pā-ˈōt-ē 

variants also peyotl

-ˈōt-ᵊl 

1

: a small, low, spineless cactus (Lophophora williamsii) of Mexico and southern Texas that has bluish- to grayish-green dome-shaped stems having jointed disk-shaped tubercles with tufts of woolly white hairs and that contains psychoactive alkaloids

called also mescal

2

: a hallucinogenic drug containing mescaline that is derived from the dried disk-shaped tops of the peyote cactus and is used especially in the religious ceremonies of some Indigenous American peoples

called also mescal

see also peyote button