Definition of peyote
1
: a hallucinogenic drug containing mescaline that is derived from the dried discoid tops of a cactus (Lophophora williamsii) and is used especially in the religious ceremonies of some American Indian peoples — see peyote button
2
: a small, low, spineless cactus (Lophophora williamsii) of the southwestern U.S. and Mexico with rounded stems having jointed tubercles with tufts of usually woolly hairs — called also
mescal
