overpotent

adjective
over·po·tent | \ ˌō-vər-ˈpō-tᵊnt \

Definition of overpotent 

: excessively potent … he was given quantities of belladonna, probably an excellent remedy, but one which proved overpotent in the case of Dr. Marston's delicate and sensitive little boy. —William Sharp

First Known Use of overpotent

1593, in the meaning defined above

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The first known use of overpotent was in 1593

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