on·​co·​gene | \ ˈäŋ-kō-ˌjēn How to pronounce oncogene (audio) \

Definition of oncogene

: a gene having the potential to cause a normal cell to become cancerous

Examples of oncogene in a Sentence

Recent Examples on the Web Traditional treatments use mutation location To attempt to answer this question, our research team chose to focus on one oncogene in lung cancer, EGFR, or epidermal growth factor receptor. Jacqulyne Robichaux, The Conversation, 25 Oct. 2021 The mutation that transforms KRAS into an oncogene locks the protein into an active state, permanently bound to GTP, causing cells to grow uncontrollably. William A. Haseltine, Forbes, 16 June 2021 In the case of cancer, this means some cells wind up with more oncogenes than the others. San Diego Union-Tribune, 19 Sep. 2019 The cancer genes, called oncogenes, were not malignant in themselves, Dr. Leder and his research team concluded. Matt Schudel, Washington Post, 15 Feb. 2020 Daughter cells with more copies of these oncogenes grow faster, as do their descendants, Mischel said. San Diego Union-Tribune, 19 Sep. 2019 The drug targets overexpressed estrogen receptors that can be predicted by the Her-2/Neu oncogene, which was discovered more than a decade earlier. Scientific American, 2 Oct. 2019 This allows mutated cancer-promoting genes called oncogenes to activate cell surface receptors, molecular portals to the cell’s interior. San Diego Union-Tribune, 13 July 2019 This drug, eFT226, blocks translation of certain oncogenes, including MYC, BCL2, cyclin D1 and CDKs 4/6. Bradley J. Fikes, sandiegouniontribune.com, 24 July 2017 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'oncogene.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of oncogene

1969, in the meaning defined above

History and Etymology for oncogene

onco- + gene

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The first known use of oncogene was in 1969

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Cite this Entry

“Oncogene.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/oncogene. Accessed 10 Aug. 2022.

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More Definitions for oncogene


on·​co·​gene | \ ˈäŋ-kō-ˌjēn How to pronounce oncogene (audio) \

Medical Definition of oncogene

: a gene having the potential to cause a normal cell to become cancerous

More from Merriam-Webster on oncogene

Britannica English: Translation of oncogene for Arabic Speakers

Britannica.com: Encyclopedia article about oncogene


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