nucleotide

noun

nu·​cle·​o·​tide ˈnü-klē-ə-ˌtīd How to pronounce nucleotide (audio)
ˈnyü-
: any of several compounds that consist of a ribose or deoxyribose sugar joined to a purine or pyrimidine base and to a phosphate group and that are the basic structural units of nucleic acids (such as RNA and DNA) compare nucleoside

Examples of nucleotide in a Sentence

Recent Examples on the Web
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Then, in 1984, a British geneticist named Alec Jeffreys discovered DNA fingerprinting, which allowed scientists to take a sample of hair, skin, or saliva and single out a sequence of nucleotides specific to one person. Jennifer Wilson, New Yorker, 18 Aug. 2025 This can also include the concentration of nucleotides coming from a living species, which can vary. Kara Nesvig, Allure, 16 Aug. 2025 For example, there are 10^623 different ways to combine nucleotides in mRNA to encode for the same protein as the company’s COVID vaccine, Davis said. Amy Feldman, Forbes.com, 23 July 2025 Using quantum algorithms based on ones IBM had previously developed for financial problems, the two companies were able to successfully predict the structure of an mRNA sequence that was about 60 nucleotides long, which is at the upper limit of what a conventional computer can do. Alex Knapp, Forbes.com, 25 July 2025 See All Example Sentences for nucleotide

Word History

Etymology

International Scientific Vocabulary, irregular from nucle- + -ide

First Known Use

1908, in the meaning defined above

Time Traveler
The first known use of nucleotide was in 1908

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Cite this Entry

“Nucleotide.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/nucleotide. Accessed 4 Sep. 2025.

Kids Definition

nucleotide

noun
nu·​cle·​o·​tide ˈn(y)ü-klē-ə-ˌtīd How to pronounce nucleotide (audio)
: any of the basic units of structure of DNA or RNA that consist of a base (as adenine, cytosine, guanine, or thymine) joined to a sugar (as deoxyribose) with five carbon atoms in a molecule and to a phosphate group

Medical Definition

nucleotide

noun
nu·​cle·​o·​tide ˈn(y)ü-klē-ə-ˌtīd How to pronounce nucleotide (audio)
: any of several compounds that consist of a ribose or deoxyribose sugar joined to a purine or pyrimidine base and to a phosphate group and that are the basic structural units of RNA and DNA compare nucleoside

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