ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

ˈser-

plural ceramides

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids

The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.

—L. Stivitz

Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.

—Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web

Testers also appreciated the inclusion of good-for-skin ingredients like ceramides and hyaluronic acid, which helps support the skin barrier. —Brigitt Earley, Glamour, 24 Apr. 2026

The rest of the formula is all about keeping skin comfortable with ceramides and betaine to lock in hydration. —Christa Joanna Lee, Allure, 22 Apr. 2026

Its Siren Capsule Technology, in particular, works to optimize skin’s collagen for lip renewal, while a blend of peptides, ceramides, hyaluronic acid spheres, and plant extracts alleviate signs of dehydration. —Kiana Murden, Vogue, 21 Apr. 2026

Focus on barrier repair overnight and look for ceramides, fatty acids and cholesterol. —Fort Worth Star-Telegram, 9 Apr. 2026

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Rhymes for ceramide

• actinide
• aldehyde
• alkoxide
• alongside
• amplified
• arsenide
• beautified
• biocide
• butoxide
• calcified
• certified
• citywide

Medical Definition

ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue