ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

ˈser-

plural ceramides

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids

The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.

—L. Stivitz

Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.

—Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web

May Help with Dry Mouth Pineapple contains a substance called glucosylceramide, which breaks down into ceramides. —Lauren O'Connor, Health, 11 Sep. 2025

The Calmer Ceramide Body Wash Testers unanimously used this unbelievably creamy conditioner with ceramides and colloidal oatmeal down to the last pump. —Jackie Fields, PEOPLE, 9 Sep. 2025

Each one is formulated with ingredients like hyaluronic acid, squalane, niacinamide, and ceramides to hydrate, support the skin barrier, and keep oil production in check. —Iman Balagam, Vogue, 31 Aug. 2025

The fragrance-free cream offers a big hit of hydration thanks to ceramides, niacinamide, glycerin, and the brand’s signature thermal spring water, which soothes the skin. —Allure, 30 Aug. 2025

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Rhymes for ceramide

• actinide
• aldehyde
• alkoxide
• alongside
• amplified
• arsenide
• beautified
• biocide
• butoxide
• calcified
• certified
• citywide

Medical Definition

ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue