ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

ˈser-

plural ceramides

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids

The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.

—L. Stivitz

Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.

—Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web

While the original launched in 2016 with a hyaluronic acid-vitamin B5 duo, its 2024 reformulation now features ceramides to improve upon the texture and double down on moisturizing benefits. — Beatrice Zocchi, Vogue, 18 Aug. 2026

While salicylic acid has a reputation for drying out skin, the triple ceramide complex in this cream counteracts that by drenching skin in long-lasting moisture—up to a full day—after application. — Mary Honkus, Glamour, 18 Aug. 2026

Zeichner suggests looking for skin-supporting ingredients such as ceramides, dimethicone, glycerin or hyaluronic acid, each of which works a little differently to keep skin hydrated, smooth and comfortable overnight. — Samantha Agate, Sacbee.com, 17 Aug. 2026

Ingredients once discussed only by dermatologists and cosmetic chemists now dominate social media feeds, while hyaluronic acid, niacinamide, peptides and ceramides have become part of everyday conversation. — Kate Hardcastle, Forbes.com, 6 Aug. 2026

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Rhymes for ceramide

• actinide
• aldehyde
• alkoxide
• alongside
• amplified
• arsenide
• beautified
• biocide
• bisulphide
• butoxide
• calcified
• certified

Medical Definition

ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue