ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

ˈser-

plural ceramides

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids

The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.

—L. Stivitz

Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.

—Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web

The lightweight, deeply hydrating and nourishing cream has antioxidants, squalene, and ceramides. —Brianna J. Heath, Essence, 20 Jan. 2026

Hyaluronic acid and ceramides work hand in hand to lock in moisture, while niacinamide calms the scalp. —Staff Author, InStyle, 18 Jan. 2026

Using deeply hydrating products, such as Eighth Day Skin’s Regenerative Serum, and occlusive moisturizers with ceramides and lipids that enhance the skin’s barrier function before clipping into your bindings is also key. —Justin Fenner, Robb Report, 17 Jan. 2026

Squalane and sodium hyaluronate help maintain hydration levels, and oat and ceramides deliver that calm, comforted feeling your barrier is likely craving. —Christa Joanna Lee, Allure, 17 Jan. 2026

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Rhymes for ceramide

• actinide
• aldehyde
• alkoxide
• alongside
• amplified
• arsenide
• beautified
• biocide
• butoxide
• calcified
• certified
• citywide

Medical Definition

ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue