nu·​cle·​ase | \ ˈnü-klē-ˌās How to pronounce nuclease (audio) , ˈnyü-, -ˌāz \

Definition of nuclease

: any of various enzymes that promote hydrolysis of nucleic acids

Examples of nuclease in a Sentence

Recent Examples on the Web Two other technologies—zinc finger nuclease and TALENS—work similarly to CRISPR-Cas9, but do so with far less ease and precision. Claire Maldarelli, Popular Science, 7 Oct. 2020 This high charge inhibits defense molecules called nucleases, proteins that degrade foreign DNA and RNA, from getting close. Scientific American, 25 Dec. 2019 In contrast, nucleases primarily result in an uncontrollable mixture of indels at the target site. Sharon Begley, STAT, 6 Nov. 2019 American scientists have carried out similar experiments on humans, with some success, using an older gene editing tool called zinc finger nuclease. Serenitie Wang, CNN, 13 Sep. 2019 The machinery involved are called TALENs (transcription activator-like effector nucleases), which are enzymes that can be customized to snip a targeted spot in a genetic code. Beth Mole, Ars Technica, 1 Sep. 2019 Her lab at the time was having steady success with a more cumbersome genome editor, transcription activatorlike effector nuclease (TALEN), the system Voytas invented. Jon Cohen, Science | AAAS, 29 July 2019 Thompson referred to other gene-editing technology called zinc-finger nucleases, which are also being investigated as a way to spur production of fetal hemoglobin. Michael Nedelman And Minali Nigam, CNN, 30 July 2019 And Sangamo Therapeutics, a company in Richmond, California, has employed an older gene editing tool called zinc finger nucleases to knock out a gene in some of the cells of HIV patients to help them resist the virus. Jocelyn Kaiser, Science | AAAS, 9 July 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'nuclease.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of nuclease

1902, in the meaning defined above

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Time Traveler for nuclease

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The first known use of nuclease was in 1902

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nuclear winter



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Cite this Entry

“Nuclease.” Dictionary, Merriam-Webster, Accessed 19 Sep. 2021.

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More Definitions for nuclease


nu·​cle·​ase | \ ˈn(y)ü-klē-ˌās, -ˌāz How to pronounce nuclease (audio) \

Medical Definition of nuclease

: any of various enzymes that promote hydrolysis of nucleic acids

More from Merriam-Webster on nuclease Encyclopedia article about nuclease


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