nu·​cle·​ase | \ ˈnü-klē-ˌās How to pronounce nuclease (audio) , ˈnyü-, -ˌāz\

Definition of nuclease

: any of various enzymes that promote hydrolysis of nucleic acids

Examples of nuclease in a Sentence

Recent Examples on the Web

And Sangamo Therapeutics, a company in Richmond, California, has employed an older gene editing tool called zinc finger nucleases to knock out a gene in some of the cells of HIV patients to help them resist the virus. Jocelyn Kaiser, Science | AAAS, "Gene edited monkeys offer hope for heart disease patients," 9 July 2018 Zhang's team created its RNA base-editor system by fusing gRNA with a different dead nuclease, dCas13, and a natural enzyme that converts A to I in RNA. Jon Cohen, Science | AAAS, "Novel CRISPR-derived 'base editors' surgically alter DNA or RNA, offering new ways to fix mutations," 25 Oct. 2017 Enzymes called nucleases can destroy the stringy substance within minutes. Aaron Rowe, WIRED, "Fight Your Migraines With a Drug Made From Left-Handed Sugars," 12 June 2008

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'nuclease.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of nuclease

1902, in the meaning defined above

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Time Traveler for nuclease

The first known use of nuclease was in 1902

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More Definitions for nuclease


nu·​cle·​ase | \ ˈn(y)ü-klē-ˌās, -ˌāz How to pronounce nuclease (audio) \

Medical Definition of nuclease

: any of various enzymes that promote hydrolysis of nucleic acids

More from Merriam-Webster on nuclease Encyclopedia article about nuclease

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incapable of being surmounted or overcome

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