nal·​trex·​one nal-ˈtrek-ˌsōn How to pronounce naltrexone (audio)
: a synthetic opiate antagonist C20H23NO4 administered in the form of its hydrochloride

Examples of naltrexone in a Sentence

Recent Examples on the Web That included the diabetes medication metformin and naltrexone, which is approved for alcohol-use disorder. Madison Muller, Fortune, 20 May 2024 For example, my work and others’ has found that people who both drink heavily and smoke cigarettes are more likely to benefit from naltrexone. Joseph P. Schacht, The Conversation, 20 May 2024 These include methadone, buprenorphine (Suboxone™), and oral and injectable depot naltrexone (Vivitrol™). Kyle J. Russell, USA TODAY, 7 May 2024 The third oral option is Contrave, a combination of the drugs bupropion and naltrexone. Kristen Jordan Shamus, Detroit Free Press, 24 July 2023 Low-dose naltrexone can be used in combination with existing medications used to manage chronic pain. Stephanie Brown, Verywell Health, 7 June 2023 Vivitrol, a monthly injection of long-acting naltrexone, is the opioid treatment preferred by the criminal prosecution system, including jails, prisons, probation officers and drug courts. Maia Szalavitz, Scientific American, 13 Sep. 2023 And naltrexone suppresses the opioid system, which can reduce cravings in both alcoholics and opiate users. Matt Hrodey, Discover Magazine, 19 June 2023 The best evidence is with naltrexone or acamprosate, both of which seem to target the underlying mechanisms of addiction. Dr. Keith Roach, oregonlive, 14 Apr. 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'naltrexone.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


N-allyl + trex- (as in methotrexate) + -one

First Known Use

1973, in the meaning defined above

Time Traveler
The first known use of naltrexone was in 1973

Dictionary Entries Near naltrexone

Cite this Entry

“Naltrexone.” Dictionary, Merriam-Webster, Accessed 24 Jun. 2024.

Medical Definition


nal·​trex·​one nal-ˈtrek-ˌsōn How to pronounce naltrexone (audio)
: a synthetic opiate antagonist administered especially in the form of its hydrochloride C20H23NO4·HCl to maintain a drug-free state in detoxified opiate-dependent patients or to maintain abstinence in alcohol-dependent patients

More from Merriam-Webster on naltrexone

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!