multiple sclerosis

noun

: a demyelinating disease marked by patches of hardened tissue in the brain or the spinal cord and associated especially with partial or complete paralysis and jerking muscle tremor

Examples of multiple sclerosis in a Sentence

Recent Examples on the Web

Christina Applegate is back home and prioritizing self-confidence in the latest update on her ongoing battle with multiple sclerosis. — Isabella Albaig, Vulture, 22 Sep. 2026

The update comes after Applegate was admitted to the hospital in late March amid her battle with multiple sclerosis. — Brendan Morrow, USA Today, 22 Sep. 2026

Christina Applegate has shared a first look at her life outside the hospital following a months-long stay amid her ongoing battle with multiple sclerosis. — Payton Turkeltaub, Variety, 21 Sep. 2026

The actress has also been candid about her multiple sclerosis (MS) diagnosis — first diagnosed in 2010 but kept private until 2022 — and plans to keep sharing her journey. — Kate Hogan, PEOPLE, 17 Sep. 2026

Word History

First Known Use

1885, in the meaning defined above

Rhymes for multiple sclerosis

• actinomycosis
• atherosclerosis
• endometriosis
• erythematosus
• erythroblastosis
• granulomatosis
• hemochromatosis
• histiocytosis
• hyperkeratosis
• ketoacidosis
• mononucleosis
• osteonecrosis

Kids Definition

multiple sclerosis

noun

: a disease marked by patches of hardened tissue in the brain or spinal cord resulting in symptoms (as weakness or paralysis in the arms or legs or loss of balance and muscle coordination) that usually come and go

Medical Definition

multiple sclerosis

noun

: a demyelinating disease marked by patches of hardened tissue in the brain or the spinal cord and associated especially with partial or complete paralysis and jerking muscle tremor