hy·​per·​ker·​a·​to·​sis | \ˌhī-pər-ˌker-ə-ˈtō-səs \
plural hyperkeratoses\ˌhī-​pər-​ˌker-​ə-​ˈtō-​ˌsēz \

Definition of hyperkeratosis 

: hypertrophy of the corneous layer of the skin

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Other Words from hyperkeratosis

hyperkeratotic \ˌhī-​pər-​ˌker-​ə-​ˈtä-​tik \ adjective

Examples of hyperkeratosis in a Sentence

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Soften Up Don’t overlook the rest of your hands: Rough patches on the palms can be remedied using a callus softener like Deborah Lippmann’s Get Off, which uses lactic acid to break down hyperkeratosis (thickening of the skin). Donna Bulseco, WSJ, "The He-Manicure: A Guide to CEO-Worthy Nails," 2 May 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'hyperkeratosis.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of hyperkeratosis

1841, in the meaning defined above

History and Etymology for hyperkeratosis

New Latin

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The first known use of hyperkeratosis was in 1841

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More Definitions for hyperkeratosis


hy·​per·​ke·​ra·​to·​sis | \-ˌker-ə-ˈtō-səs \
plural hyperkeratoses\-​ˈtō-​ˌsēz \

Medical Definition of hyperkeratosis 

1 : hypertrophy of the stratum corneum layer of the skin

2a : any of various conditions marked by hyperkeratosis

b : a disease of cattle that is marked by thickening and wrinkling of the hide, by formation of papillary outgrowths on the buccal mucous membranes, and often by a watery discharge from eyes and nose, diarrhea, loss of weight, and abortion of pregnant animals and that is caused especially by ingestion of the chlorinated naphthalene of various lubricating oils, by arsenic poisoning, or by inherited congenital ichthyosis

called also X-disease, XX disease

Other Words from hyperkeratosis

hyperkeratotic \-​ˈtät-​ik \ adjective

More from Merriam-Webster on hyperkeratosis

Britannica.com: Encyclopedia article about hyperkeratosis

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a nest or breeding place

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