mono·​va·​lent | \ ˌmä-nə-ˈvā-lənt How to pronounce monovalent (audio) \

Definition of monovalent

1 : having a valence of one
2 : having specific immunologic activity against a single antigen, microorganism, or disease a monovalent vaccine

Examples of monovalent in a Sentence

Recent Examples on the Web Although the level of antibodies was lower than with a monovalent vaccine, the breadth of coverage was greater. Laura Defrancesco, Scientific American, 6 Jan. 2022 Moderna also said that the National Institute of Allergy and Infectious Diseases (NIAID) would conduct a Phase 1 clinical trial to study both the monovalent and multivalent versions of mRNA-1273 vaccines. Chris Smith, BGR, 12 Mar. 2021 The plan was to snuff out the few type 2 outbreaks that would inevitably emerge from the last use of trivalent vaccine with a limited, emergency stockpile of a vaccine effective against just type 2, known as monovalent OPV2 (mOPV2). Leslie Roberts, Science | AAAS, 10 Nov. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'monovalent.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of monovalent

1871, in the meaning defined at sense 1

History and Etymology for monovalent

International Scientific Vocabulary

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Time Traveler for monovalent

Time Traveler

The first known use of monovalent was in 1871

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Dictionary Entries Near monovalent



monovalent antibody

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Last Updated

9 Jan 2022

Cite this Entry

“Monovalent.” Dictionary, Merriam-Webster, Accessed 22 Jan. 2022.

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More Definitions for monovalent


mono·​va·​lent | \ ˌmän-ə-ˈvā-lənt How to pronounce monovalent (audio) \

Medical Definition of monovalent

1 : having a chemical valence of one
2 : containing antibodies specific for or antigens of a single strain of a microorganism a monovalent vaccine


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