metastasize

verb

me·​tas·​ta·​size mə-ˈta-stə-ˌsīz 

metastasized; metastasizing

intransitive verb

: to spread or grow by or as if by metastasis

… died of lung cancer which had metastasized throughout his body.

—G. P. Elliott

Examples of metastasize in a Sentence

Recent Examples on the Web

During the past quarter century, terrorism has metastasized, and not only in the Middle East. — Robin Wright, New Yorker, 11 Sep. 2026

Among Michigan's first histotripsy patients was Elissa Robinson, a Detroit Free Press web editor with colon cancer that had metastasized to her liver. — Kristen Jordan Shamus, Freep.com, 10 Sep. 2026

Sam Rockwell, Marin Ireland, and Alfred Molina lead a buzzy revival of the Arthur Miller play — about a Red Hook longshoreman whose protectiveness toward his teenage niece metastasizes into violent obsession — at, of all places, La MaMa. — Jackson McHenry, Vulture, 8 Sep. 2026

Biden’s office announced in May 2025 that the former president had been diagnosed with an aggressive form of prostate cancer that had metastasized to his bones. — Jasmine Baehr, FOXNews.com, 8 Sep. 2026

Word History

First Known Use

1907, in the meaning defined above

Rhymes for metastasize

• actualize
• antagonize
• apologise
• apologize
• capitalize
• categorize
• characterize
• commercialize
• conceptualize
• contrariwise
• criminalize
• decentralize

Kids Definition

metastasize

verb

me·​tas·​ta·​size mə-ˈtas-tə-ˌsīz 

: to spread or grow by or as if by metastasis

Medical Definition

metastasize

intransitive verb

me·​tas·​ta·​size

variants also British metastasise

mə-ˈtas-tə-ˌsīz 

metastasized also British metastasised; metastasizing also British metastasising

: to spread by metastasis

… all ten were primary brain cancers; that is, they had originated in the brain, and not metastasized there from elsewhere in the body.

—Paul Brodeur, The New Yorker

metastasization noun

also British metastasisation

mə-ˌtas-tə-sə-ˈzā-shən