mast cell


: a granulocyte that occurs especially in connective tissue and has basophilic granules containing substances (such as histamine and heparin) which mediate allergic reactions

Examples of mast cell in a Sentence

Recent Examples on the Web The number of mast cells is typically normal.5 However, with systemic mastocytosis, mast cells abnormally accumulate in various tissues, including the skin, bone marrow, and internal organs. Sarah Jividen, Verywell Health, 15 July 2024 In 2022, Halsey was diagnosed with Ehlers-Danlos syndrome, Sjogren’s syndrome, mast cell activation syndrome, and postural orthostatic tachycardia syndrome. Jason P. Frank, Vulture, 4 June 2024 Ehlers-Danlos syndrome, POTS (postural orthostatic tachycardia syndrome), Sjogren’s syndrome, and MCAS (mast cell activation syndrome). Wesley Stenzel,, 5 June 2024 In May 2022 Halsey revealed they had been diagnosed with Ehlers-Danlos syndrome, Sjogren's syndrome, mast cell activation syndrome and POTS (postural tachycardia syndrome). Ilana Kaplan, Peoplemag, 4 June 2024 Some evidence suggests that mast cells (a type of immune cell) release histamine when they're activated. Samantha Lauriello, Health, 26 May 2024 Unlike steroids, decongestants, antihistamines, and saline sprays, this brand is a mast cell inhibitor spray. Shannon Ullman, Health, 6 May 2024 With the complications of mast cell activation syndrome, including drops in blood pressure, flushing, severe itching and rashes, Ms. Banks relied on alternative therapies, including reiki, hypnosis, emotional freedom technique, quantum healing and regression therapy. Alex Williams, New York Times, 27 Mar. 2024 Other conditions, including chronic Lyme, mast cell activation syndrome, Ehlers-Danlos syndrome, POTS, and myalgic encephalomyelitis/chronic fatigue syndrome, or ME/CFS, have mostly been ignored. Isabella Cueto, STAT, 15 Mar. 2024

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'mast cell.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


partial translation of German Mastzelle, from Mast food, mast (from Old High German) + Zelle cell

First Known Use

circa 1890, in the meaning defined above

Time Traveler
The first known use of mast cell was circa 1890

Dictionary Entries Near mast cell

Cite this Entry

“Mast cell.” Dictionary, Merriam-Webster, Accessed 19 Jul. 2024.

Medical Definition

mast cell

: a granulocyte that occurs especially in connective tissue and has basophilic granules containing substances (as histamine and heparin) which mediate allergic reactions

More from Merriam-Webster on mast cell

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