isolate

1 of 3

verb

iso·​late ˈī-sə-ˌlāt 

 also  ˈi-

isolated; isolating

transitive verb

1

: to set apart from others

also : quarantine

2

: to select from among others

especially : to separate from another substance so as to obtain pure or in a free state

3

: insulate

isolator

ˈī-sə-ˌlā-tər 

 also  ˈi-

noun

isolate

2 of 3

adjective

iso·​late ˈī-sə-lət  -ˌlāt 

 also  ˈi-

: being alone : solitary, isolated

isolate

3 of 3

noun

iso·​late ˈī-sə-lət  -ˌlāt 

 also  ˈi-

1

: an individual, population, strain, or culture obtained by or resulting from selection or separation

2

: an individual socially withdrawn or removed from society

Synonyms

Verb

• separate
• segregate
• remove
• insulate

Noun

• hermit
• solitary

Examples of isolate in a Sentence

Verb

These policies will only serve to isolate the country politically and economically.

Certain patients must be isolated in a separate ward.

When he wants to work, he isolates himself in his office and won't talk to anyone.

Scientists have isolated the gene that causes the disease.

Noun

interpersonal relationships are very stressful for him, so he lives as a virtual isolate

Recent Examples on the Web

Verb

The tide could be a foot higher than the point where major flooding begins that can produce severe damage to homes and businesses, making some roads impassable and isolating neighborhoods. —Dinah Voyles Pulver, USA Today, 11 Oct. 2025

Scenes from Gaza of devastation and hunger, as well as a famine declaration, have prompted outrage around the world and left Israel isolated diplomatically. —Yamiche Alcindor, NBC news, 10 Oct. 2025

Noun

By comparison, clear protein is composed of whey protein isolate—a version of whey protein concentrate that has been further refined to remove the fat and carbs, according to Dada. —Caroline Tien, SELF, 13 Oct. 2025

Many meat substitutes are ultra-processed, filled with sodium, inflammatory oils, and synthetic additives like methylcellulose and soy protein isolate. —Dr. Sanjay Bhojraj, CNBC, 10 Oct. 2025

Word History

Etymology

Verb

back-formation from isolated set apart, from French isolé, from Italian isolato, from isola island, from Latin insula

First Known Use

Verb

1799, in the meaning defined at sense 1

Adjective

1819, in the meaning defined above

Noun

1890, in the meaning defined at sense 1

Phrases Containing isolate

• self-isolate

Rhymes for isolate

• abdicate
• abrogate
• acetate
• activate
• actuate
• adsorbate
• aggravate
• agitate
• alginate
• alienate
• allocate
• amputate

Kids Definition

isolate

verb

iso·​late

ˈī-sə-ˌlāt,

 also  ˈis-ə-

isolated; isolating

: to set or keep apart from others

Etymology

Verb

derived from French isolé (adjective) "isolated, set off from others," from Italian isola "island," from Latin insula "island" — related to insulate, isle, peninsula

Medical Definition

isolate

1 of 2 transitive verb

iso·​late ˈī-sə-ˌlāt 

isolated; isolating

: to set apart from others: as

a

: to separate (one with a contagious disease) from others not similarly infected

b

: to separate (as a chemical compound) from all other substances : obtain pure or in a free state

isolate

2 of 2 noun

iso·​late ˈī-sə-lət  -ˌlāt 

1

: an individual (as a spore or single organism), a viable part of an organism (as a cell), or a strain that has been isolated (as from diseased tissue, contaminated water, or the air)

also : a pure culture produced from such an isolate

2

: a relatively homogeneous population separated from related populations by geographic, biologic, or social factors or by human intervention

3

: a socially withdrawn individual