isolate

1 of 3

verb

iso·​late ˈī-sə-ˌlāt 

also ˈi-

isolated; isolating

transitive verb

1

: to set apart from others

also : quarantine

2

: to select from among others

especially : to separate from another substance so as to obtain pure or in a free state

3

: insulate

isolator

ˈī-sə-ˌlā-tər 

also ˈi-

noun

isolate

2 of 3

adjective

iso·​late ˈī-sə-lət  -ˌlāt 

also ˈi-

: being alone : solitary, isolated

isolate

3 of 3

noun

iso·​late ˈī-sə-lət  -ˌlāt 

also ˈi-

1

: an individual, population, strain, or culture obtained by or resulting from selection or separation

2

: an individual socially withdrawn or removed from society

Synonyms of isolate

Verb

• separate
• segregate
• remove
• insulate

Noun

• hermit
• solitary

Examples of isolate in a Sentence

Verb

These policies will only serve to isolate the country politically and economically.

Certain patients must be isolated in a separate ward.

When he wants to work, he isolates himself in his office and won't talk to anyone.

Scientists have isolated the gene that causes the disease.

Noun

interpersonal relationships are very stressful for him, so he lives as a virtual isolate

Recent Examples on the Web

Verb

Cybergenetics isolated the unknown person’s genotypes from each DNA sample and compared them to determine whether the cases were connected. — Maria Aguilar Prieto, CNN Money, 8 Nov. 2026

In 1997 the City of Annapolis isolated Eastport when the Spa Creek bridge was temporarily closed for unannounced repairs. — Nats_syndicator, Baltimore Sun, 7 Nov. 2026

Noun

Whey protein isolate, a more purified whey variety, is lower in lactose and fat than whey protein concentrate and may be easier to digest. — Maggie Donahue, HEALTH, 5 Nov. 2026

Among nearly 17,000 Shigella species isolates with resistance data, extensively drug-resistant (XDR) isolates increased between 2011 and 2023, according to an analysis by the CDC. — Devika Rao, TheWeek, 23 Oct. 2026

Word History

Etymology

Verb

back-formation from isolated set apart, from French isolé, from Italian isolato, from isola island, from Latin insula

First Known Use

Verb

1799, in the meaning defined at sense 1

Adjective

1819, in the meaning defined above

Noun

1890, in the meaning defined at sense 1

Phrases Containing isolate

• self-isolate

Rhymes for isolate

• abdicate
• abrogate
• acetate
• activate
• actuate
• aggravate
• agitate
• alginate
• alienate
• allocate
• amputate
• angulate

Kids Definition

isolate

verb

iso·​late

ˈī-sə-ˌlāt

also ˈis-ə-

isolated; isolating

: to set or keep apart from others

Etymology

Verb

derived from French isolé (adjective) "isolated, set off from others," from Italian isola "island," from Latin insula "island" — related to insulate, isle, peninsula

Medical Definition

isolate

1 of 2 transitive verb

iso·​late ˈī-sə-ˌlāt 

isolated; isolating

: to set apart from others: as

a

: to separate (one with a contagious disease) from others not similarly infected

b

: to separate (as a chemical compound) from all other substances : obtain pure or in a free state

isolate

2 of 2 noun

iso·​late ˈī-sə-lət  -ˌlāt 

1

: an individual (as a spore or single organism), a viable part of an organism (as a cell), or a strain that has been isolated (as from diseased tissue, contaminated water, or the air)

also : a pure culture produced from such an isolate

2

: a relatively homogeneous population separated from related populations by geographic, biologic, or social factors or by human intervention

3

: a socially withdrawn individual